Skip to main content

Hypertriglyceridemia and hyperuricemia: a retrospective study of urban residents



The aim of this study was to determine the association between hypertriglyceridemia and hyperuricemia (HUA).


The study was conducted in 3884 subjects who had not received medication enrolled as a baseline. Each participant received at least three annual health check-ups between 2011 and 2017. The risk of hyperuricemia was assessed in four Quartiles (Q1 to Q4) according to TG levels using multivariate-adjusted logistic regression models.


The total incidence rate of HUA was 62.3/1000 person-years. In the univariate analysis, the risk of hyperuricemia in people with hypertriglyceridemia was 2.353 times that of normal triglycerides, with a 95% confidence interval of (2.011, 2.754), and the risk of hyperuricemia in men was 1.86 times of female, and the 95% confidence interval is (1.634, 2.177). After adjusting the potential confounders, the relative risk RR of TG at Q2 Q3 Q4 was 1.445 (95%CI:1.114, 1.901), 2.075 (1.611, 2.674), 2.972 (2.322, 3.804).


TG is an independent risk factor for hyperuricemia. As the level of TG increases, the risk of HUA increases.


With the improvement of people’s living standards, the prevalence of metabolic diseases is also increasing. Hyperuricemia and hypertriglyceridemia are metabolic diseases. The prevalence of hyperuricemia in the world has been increasing over the past few decades [1]. Serum uric acid (SUA) is mainly produced by purines metabolism, and it has been proven to play emerging roles in human disease including metabolic syndrome and gout [2,3,4]. When the concentration of urate in the extracellular fluid is too high, urate crystals are formed, which leads to gout and seriously affects the quality of life. The level of serum uric acid is determined by production and the net balance of reabsorption or secretion by the kidney and intestine [5]. There are many risk factors for hyperuricemia. Some studies have shown that obesity, hypertension, total cholesterol, serum bisphenol A (Bisphenol A) and alcohol intake may increase the risk of HUA [6]. Intake of vitamin C and dairy products may lower serum uric acid levels [7,8,9]. Hypertriglyceridemia is a disorder of lipoprotein metabolism, which refers to serum triglyceride > 1.70 mmol / L, and it is a risk factor for cardiovascular disease and diabetes [10]. Japanese scholars have studied middle-aged men and pointed out that high triglycerides are risk factors for hyperuricemia [7]. Hypertriglyceridemia and hyperuricemia are also associated with cardiovascular disease, hypertension, obesity and insulin resistance [11,12,13]. This study used a complete physical examination data to establish a retrospective study to estimate the relationship between hypertriglyceridemia and hyperuricemia.


Study population

In this study, the data were selected from the medical examination population in the hospital in 2011. The criteria for personnel selection was more than two follow-ups since 2011. The first physical examination data of subjects was complete, and all subject did not receive medication, with a total of 3884 people serving as study, including 2060 males (age: 46.40 ± 11.29) and 1824 females (age: 42.24 ± 10.70), a total of 47 people was failed to follow up finally, and the rate of loss of follow-up was 1.2%. The first physical examination data was used as the baseline, and the study was divided into the normal group (n = 1686) and the elevated triglyceride group (n = 2198) according to the initial triglyceride level. Meanwhile, the study was divided into the HUA group (n = 720) and non-HUA group (n = 3164) according to whether the outcome occurred or not. The study was approved by the Ethics Committee of the Lanzhou University Second Hospital.


HUA criteria: serum uric acid (SUA) male ≥420 μmol / L, female ≥360 μmol / L. Abnormal criteria for other indicators: BMI ≥ 25 kg/m2; blood urea nitrogen (BUN) > 7.1 mmol / L; serum creatinine (CR) men > 106 μmol / L, women > 97 μmol / L; blood glucose (GLU) > 7.0 mmol / L; triglycerides (TG) > 1.7 mmol/L; total cholesterol (CHOL) > 5.72 mmol/L; high-density lipoprotein (HDL) < 0.90 mmol/L; low-density lipoprotein (LDL) > 3.12 mmol/L.


All items were measured with an automatic biochemical analyzer (HITACHI 7600, JAPAN).

Statistical methods

Data processing was performed using EXCEL and SPSS 22.0. The baseline characteristics and outcomes were statistically described as mean ± standard deviation (SD). The continuous variables were tested by t-test and the categorical variables were analyzed by χ2 test. The relationship between TG and HUA was analyzed by Cox regression model. A P value less than 0.05 was considered statistically significant.


  1. 1.

    Baseline characteristics of the study population are shown in Table 1. The baseline characteristics of the TG normal group and the TG elevated group were significantly different (p < 0.001).

  2. 2.

    Ending characteristics of the study population description are shown in Table 2. Among males, BMI, serum creatinine, blood uric acid and triglyceride in HUA group were higher than that in the non-HUA group; in women, HUA group age, serum creatinine, blood uric acid, blood sugar, triglyceride and total cholesterol were higher than non-HUA groups, and all had significant differences (p < 0.001).

  3. 3.

    The incidence of HUA with different gender with age is shown in Table 3. The incidence of women increases with age, and the change in men is not significant. The increase in the incidence of women is later than that of men.

  4. 4.

    Single factor analysis of hyperuricemia is shown in Table 4. The risk of hyperuricemia with hypertriglyceridemia is 2.353 times that of normal triglycerides, 95% confidence interval is (2.011, 2.754), People with hypercholesterolemia are 1.385 times more likely to develop hyperuricemia than normal people, and the risk of hyperuricemia in men is 1.886 times that of women, 95% confidence interval is (1.634, 2.177).

  5. 5.

    The incidence of HUA in different TG populations is shown in Table 5. The TG levels were divided into Q1, Q2, Q3, and Q4 from low to high. With the TG level increased, the incidence density also increased.

  6. 6.

    TG and HUA incidence correlation Cox regression analysis results are shown in Table 6.

Table 1 Baseline characteristics of the study population
Table 2 Outcome characteristics of the study population
Table 3 Gender incidence with age
Table 4 Single factor analysis of hyperuricemia
Table 5 HUA status of different TG levels
Table 6 Analysis of associations between baseline triglyceride levels and incident HUA (OR: 95% CI)


The characteristics of the outcomes in this study (Table 2) showed that the male and female from the HUA group and the non-HUA group had different degrees of difference in various indicators. For males, BMI, serum creatinine, blood uric acid, and triglyceride levels were higher for those in the HUA group than for those in the non-HUA group; among women, age, serum creatinine, serum uric acid, blood glucose, triglyceride, and total cholesterol levels were higher for those in the HUA group than for those in the non-HUA group. The possible reason for the gender difference is that the number of populations is insufficient. Another possible cause is estrogen. Some studies have shown that women before the menopause presented uric acid levels of around 60 μmol / L, which is lower than men’s. High levels of estrogen may promote excretion of uric acid, more effective removal of urate, and an increase in uric acid level after menopause [14]. Similarly, uric acid levels have decreased in men treated with estrogen, and the specific mechanism of the action of estrogen remains to be further studied [15, 16]. Body mass index (BMI) was associated with the prevalence of hyperuricemia, especially in the middle-aged, urban Chinese men [17]. In our study, the population with hyperuricemia had higher BMI for men. However, there is no significant difference in BMI among women. It might be related to men’s weight gain in adulthood and alcohol consumption.

Table 3 shows that there is a gender difference in the occurrence of hyperuricemia. The male incidence rate is higher than females’, which may be related to factors such as diet (there are more males than females who smoke) and physical condition (height and weight). Moreover, the incidence of HUA (18.5%) in this study was higher than that in rural areas of Northeast China (10.9%) and mainland China (13.3, 19.4% in men and 7.9% in women), which may be related to population structure, economic development and eating habits since rapid economic growth affects previous lifestyles [18, 19]. Hyperuricemia was more common in urban populations than in rural populations and the incidence was higher in inland areas than in coastal areas [20].

The incidence density of hyperuricemia increases significantly with higher triglyceride levels, suggesting that lowering triglyceride levels may reduce the risk of hyperuricemia. This result is consistent with the results of Yuan Zhang et al. [21]. Although the specific mechanism of the increase of TG level and hyperuricemia has not been elucidated. Some scholars have suggested that it may be due to the disorder of free fatty acids metabolism caused by triglyceride, as the increase of triglyceride leads to increased free fatty acid production. Accelerating the decomposition of adenosine triphosphate, which leads to an increase in uric acid, the end product of purine metabolism [22]. Some studies have shown that the synthesis of fatty acids in the liver is linked to the synthesis of the de novo purine and the accelerated production of urea [23]. The effects of triglyceride metabolic disorder on hyperuricemia remain to be further elucidated. Numerous factors may affect serum triglyceride levels, include high blood pressure, body mass index (BMI), age, gender, obesity, diet, lifestyle, and many other potential factors [24,25,26].

In this study, blood glucose, blood urea nitrogen, serum creatinine, high-density lipoprotein, and low-density lipoprotein were not significantly associated with HUA (p > 0.05). Triglycerides, total cholesterol, and gender were associated with the occurrence of HUA (p < 0.05). The incidence density and OR values were 103.1/1000 person-years and 2.972 (model 3), respectively, which were higher than these of TG levels at Q1, Q2, and Q3.

The results of this study showed that after adjusting for confounding factors, the occurrence of HUA was significantly affected when the TG level is significantly higher than the normal range. Therefore, strengthening the monitoring of serum TG levels can be used as a basis for preventing HUA.

The innovation of this study is that it uses more than 3 years of study data, which are more valuable than the case-control study results. In addition, this study compares the initial baseline and outcome characteristics of the population to enhance the persuasiveness of the conclusion.

The limitation of this study is the missing data and the physical examination data are not enough to fulfill the requirement of completeness. There are many important factors affecting hyperuricemia, but the diagnosis is only based on a single examination data, so there will be bias. In addition, the data collected is not complete, there are no data on smoking, drinking, and other socio-economic factors, and thus the description of the population’s characteristics is lacking.


TG is an independent risk factor for HUA. As the level of TG increases, the risk of HUA increases.



Body mass index


Blood urea nitrogen


Total cholesterol


Blood glucose


High-density lipoprotein


Low-density lipoprotein


Serum creatinine


Serum uric-acid




  1. Trifiro G, Morabito P, Cavagna L, et al. Epidemiology of gout and hyperuricaemia in Italy during the years 2005-2009: a nationwide population-based study. Ann Rheum Dis. 2013;72:694–700.

    CAS  Article  Google Scholar 

  2. Abbasian M, Ebrahimi H, Delvarianzadeh M, Norouzi P, Fazli M. Association between serum uric acid (SUA) levels and metabolic syndrome (MetS) components in personnel of Shahroud University of Medical Sciences. Diab Metab Syndr. 2016;10:132–6.

    Article  Google Scholar 

  3. Nejatinamini S, Ataie-Jafari A, Qorbani M, et al. Association between serum uric acid level and metabolic syndrome components. J Diabetes Metab Disord. 2015;14:70.

    Article  Google Scholar 

  4. Sui X, Church TS, Meriwether RA, Lobelo F, Blair SN. Uric acid and the development of metabolic syndrome in women and men. Metabolism. 2008;57:845–52.

    CAS  Article  Google Scholar 

  5. Mandal AK, Mount DB. The molecular physiology of uric acid homeostasis. Annu Rev Physiol. 2015;77:323–45.

    CAS  Article  Google Scholar 

  6. Villegas R, Xiang YB, Elasy T, et al. Purine-rich foods, protein intake, and the prevalence of hyperuricemia: the Shanghai Men’s health study. Nutr Metab Cardiovasc Dis. 2012;22:409–16.

    CAS  Article  Google Scholar 

  7. Nakanishi N, Tatara K, Nakamura K, Suzuki K. Risk factors for the incidence of hyperuricaemia: a 6-year longitudinal study of middle-aged Japanese men. Int J Epidemiol. 1999;28:888–93.

    CAS  Article  Google Scholar 

  8. Hu J, Peng C, Li J, et al. Serum bisphenol A is an independent risk factor of hyperuricemia: a 6-year prospective study. Semin Arthritis Rheum. 2019;48(4):644-8.

  9. Makinouchi T, Sakata K, Oishi M, et al. Benchmark dose of alcohol consumption for development of hyperuricemia in Japanese male workers: an 8-year cohort study. Alcohol. 2016;56:9–14.

    CAS  Article  Google Scholar 

  10. Kametani T, Koshida H, Nagaoka T, Miyakoshi H. Hypertriglyceridemia is an independent risk factor for development of impaired fasting glucose and diabetes mellitus: a 9-year longitudinal study in Japanese. Intern Med. 2002;41:516.

    Article  Google Scholar 

  11. Braga F, Pasqualetti S, Ferraro S, Panteghini M. Hyperuricemia as risk factor for coronary heart disease incidence and mortality in the general population: a systematic review and meta-analysis. Clin Chem Lab Med. 2016;54:7–15.

    CAS  Article  Google Scholar 

  12. Mazza A, Lenti S, Schiavon L, et al. Asymptomatic hyperuricemia is a strong risk factor for resistant hypertension in elderly subjects from general population. Biomed Pharmacother. 2017;86:590–4.

    CAS  Article  Google Scholar 

  13. Chen JH, Pan WH, Hsu CC, et al. Impact of obesity and hypertriglyceridemia on gout development with or without hyperuricemia: a prospective study. Arthritis Care Res (Hoboken). 2013;65:133–40.

    Article  Google Scholar 

  14. Guan S, Tang Z, Fang X, et al. Prevalence of hyperuricemia among Beijing post-menopausal women in 10 years. Arch Gerontol Geriatr. 2016;64:162–6.

    CAS  Article  Google Scholar 

  15. Elisabeth HA, Choi HK. Menopause, postmenopausal hormone use and serum uric acid levels in US women – the third National Health and nutrition examination survey. Arthritis Res Ther. 2008;10:1–7.

    Google Scholar 

  16. Nicholls A, Snaith ML, Scott JT. Effect of Oestrogen therapy on plasma and urinary levels of uric acid. Br Med J. 1972;2:449–51.

    Article  Google Scholar 

  17. Villegas R, Xiang YB, Cai Q, et al. Prevalence and determinants of hyperuricemia in middle-aged, urban Chinese men. Metab Syndr Relat Disord. 2010;8:263–70.

    Article  Google Scholar 

  18. Yu S, Yang H, Guo X, et al. Prevalence of hyperuricemia and its correlates in rural northeast Chinese population: from lifestyle risk factors to metabolic comorbidities. Clin Rheumatol. 2016;35:1207–15.

    Article  Google Scholar 

  19. Yano Y, Fujimoto S, Asahi K, Watanabe T. Prevalence of chronic kidney disease in China. Lancet. 2012;380:213–4.

    Article  Google Scholar 

  20. Liu R, Han C, Wu D, et al. Prevalence of hyperuricemia and gout in mainland China from 2000 to 2014: a systematic review and meta-analysis. Biomed Res Int. 2015;2015:762820.

    PubMed  PubMed Central  Google Scholar 

  21. Zhang Y, Wei F, Chen C, et al. Higher triglyceride level predicts hyperuricemia: a prospective study of 6-year follow-up. J Clin Lipidol. 2018;12:185–92.

    Article  Google Scholar 

  22. Balasubramanian T. Uric acid or 1-methyl uric acid in the urinary bladder increases serum glucose, insulin, true triglyceride, and total cholesterol levels in Wistar rats. ScientificWorldJournal. 2003;3:930–6.

    CAS  Article  Google Scholar 

  23. Matsuura F, Yamashita S, Nakamura T, et al. Effect of visceral fat accumulation on uric acid metabolism in male obese subjects: visceral fat obesity is linked more closely to overproduction of uric acid than subcutaneous fat obesity. Metabolism. 1998;47:929–33.

    CAS  Article  Google Scholar 

  24. Erem C, Hacihasanoglu A, Deger O, Kocak M, Topbas M. Prevalence of dyslipidemia and associated risk factors among Turkish adults: Trabzon lipid study. Endocrine. 2008;34:36–51.

    CAS  Article  Google Scholar 

  25. Nilsson SK, Heeren J, Olivecrona G, Merkel M. Apolipoprotein A-V; a potent triglyceride reducer. Atherosclerosis. 2011;219:15–21.

    CAS  Article  Google Scholar 

  26. Su P, Hong L, Zhao Y, Sun H, Li L. Relationship between hyperuricemia and cardiovascular disease risk factors in a Chinese population: a cross-sectional study. Med Sci Monit. 2015;21:2707–17.

    CAS  Article  Google Scholar 

Download references


The authors thank Professor Xiaobin Hu for his guidance on statistical methods. Thanks also to Professor Shengxiang Zhang for helpful language editing.


This work was supported by National Natural Science Foundation of China (Grant No. 81560343), Science and Technology Plan Project of Gansu (18YF1FA108), Lanzhou University Second Hospital Doctoral Research Fund Project (Ynbskyjj2015-1-6).

Availability of data and materials

The datasets during and/or analyzed during the current study are available from the corresponding author on reasonable request.

Author information

Authors and Affiliations



YH and CY designed the study; XY, CW, LZ and MY collected biochemical data; YH and CY drafted the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Chong-ge You.

Ethics declarations

Ethics approval and consent to participate

The study was approved by the Ethics Committee of the Lanzhou University Second Hospital.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Hou, Yl., Yang, Xl., Wang, Cx. et al. Hypertriglyceridemia and hyperuricemia: a retrospective study of urban residents. Lipids Health Dis 18, 81 (2019).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI:


  • Hyperuricemia; triglyceride
  • Uric acid
  • Metabolism