Circulating growth differentiation factor 15 levels and apolipoprotein B to apolipoprotein A1 ratio in coronary artery disease patients with type 2 diabetes mellitus

Table 3 Association of coronary heart diseases with serum Apo B/Apo A1 ratios in T2DM patients

ApoB/ApoA1 quartiles	n	Ratio range	OR (95%CI)
ApoB/ApoA1 quartiles	n	Ratio range	Crude	Model 1	Model 2
Quartile 1(low)	122	≤0.5772	Reference	Reference	Reference
Quartile 2	130	0.5772–0.7358	1.171(1.026,2.852)	1.784(1.007,3.161)	1.310(0.580,2.961)
Quartile 3	124	0.7358–0.8716	2.850(1.707,4.759)	3.237(1.821,5.754)	2.342(1.291,7.402)
Quartile 4(high)	125	≥0.8716	2.867(1.714,4.798)	3.327(1.864,5.940)	2.388(1.891,10.245)
β			−0.366	−0.286	−0.351
SE			0.083	0.091	0.135
p value			< 0.001	< 0.002	0.001

Logistic regression was used to examine the associations between serum levels of GDF-15 and coronary artery diseases in T2DM patients. Serum GDF-15 was divided into quartiles (quartile 4: ≥75th, quartile 3: 50–75th, quartile 2: 25–50th, quartile 1: < 25th percentile)
Crude: no adjustment
Model 1: adjusted for age, gender, diabetic durations, BMI, alcohol drinking, smoking, hypertension, insulin, metformin and anti-hypertension treatments
Model 2: adjusted for the same variables as Model 1 as well as GDF-15, WBC, NEU, LYM, NLR, hs-CRP, HbA1c, FPG, 2hPG, GA, GA/ALB, ALT, AST, GGT, Urea, Cr, UA, eGFR, FFA, TC, TG, HDL-C, and LDL-C

ISSN: 1476-511X