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Table 4 NHR levels in relation to cardiovascular outcomes in patients with pre-diabetes

From: Neutrophil to high-density lipoprotein cholesterol ratio predicts adverse cardiovascular outcomes in subjects with pre-diabetes: a large cohort study from China

  

HR (95% CI)

Variables

Events/subjects

Crude model

P value

model 1

P value

model 2

P value

NGR

 NHR (per SD change)a

6143/119705

1.11(1.08-1.13)

<0.001

1.12(1.09-1.15)

<0.001

1.08(1.05-1.11)

<0.001

 NHR (continuous change)a

6143/119705

1.26(1.19-1.33)

<0.001

1.30(1.23-1.37)

<0.001

1.19(1.12-1.26)

<0.001

Pre-DM

 NHR (per SD change)a

870/11096

1.18(1.10-1.26)

<0.001

1.18(1.10-1.26)

<0.001

1.16(1.08-1.24)

<0.001

 NHR (continues change)a

870/11096

1.44(1.24-1.68)

<0.001

1.45(1.24-1.69)

<0.001

1.40(1.19-1.64)

<0.001

NGR

 NHR Q1

1351/31189

Reference

 

Reference

 

Reference

 

 NHR Q2

1551/30095

1.21 (1.12-1.30)

<0.001

1.21(1.13-1.30)

<0.001

1.15(1.07-1.24)

<0.001

 NHR Q3

1640/29601

1.34 (1.25-1.44)

<0.001

1.36(1.26-1.46)

<0.001

1.26(1.17-1.35)

<0.001

 NHR Q4

1601/28820

1.38 (1.29-1.49)

<0.001

1.43(1.33-1.54)

<0.001

1.28(1.19-1.38)

<0.001

Pre-DM

 NHR Q1

161/2487

1.53 (1.30-1.81)

<0.001

1.36(1.16-1.61)

<0.001

1.17(0.98-1.39)

0.083

 NHR Q2

204/2827

1.74 (1.50-2.01)

<0.001

1.49(1.29-1.73)

<0.001

1.27(1.08-1.49)

0.004

 NHR Q3

244/2835

2.13 (1.85-2.44)

<0.001

1.80(1.57-2.06)

<0.001

1.48(1.27-1.72)

<0.001

 NHR Q4

261/2947

2.30 (2.02-2.63)

<0.001

2.01(1.76-2.29)

<0.001

1.60(1.38-1.86)

<0.001

 P for trend

  

<0.001

 

<0.001

 

<0.001

  1. aLog-transformed NHR; Model 1 adjusted for age, gender, smoker, drinker, education, physical activity. Model 2 adjusted for age, gender, smoker, drinker, education, physical activity, obesity, hypertension, dyslipidemia, C-reactive protein and fasting blood glucose. NHR Neutrophil to high-density lipoprotein cholesterol level ratio, NGR Normal glucose regulation, pre-DM Pre-diabetes mellitus