Rana S, Lemoine E, Granger JP, Karumanchi SA. Preeclampsia: pathophysiology, challenges, and perspectives. Circ Res. 2019;124:1094–112.
Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists' task force on hypertension in pregnancy. Obstet Gynecol. 2013;122:1122–31.
ACOG Practice Bulletin No. 202 summary: gestational hypertension and preeclampsia. Obstet Gynecol. 2019;133:1.
Duan DM, Niu JM, Lei Q, Lin XH, Chen X. Serum levels of the adipokine chemerin in preeclampsia. J Perinat Med. 2011;40:121–7.
Clausen T, Djurovic S, Henriksen T. Dyslipidemia in early second trimester is mainly a feature of women with early onset pre-eclampsia. BJOG. 2001;108:1081–7.
Wojcik-Baszko D, Charkiewicz K, Laudanski P. Role of dyslipidemia in preeclampsia-a review of lipidomic analysis of blood, placenta, syncytiotrophoblast microvesicles and umbilical cord artery from women with preeclampsia. Prostaglandins Other Lipid Mediat. 2018;139:19–23.
Spracklen CN, Smith CJ, Saftlas AF, Robinson JG, Ryckman KK. Maternal hyperlipidemia and the risk of preeclampsia: a meta-analysis. Am J Epidemiol. 2014;180:346–58.
He B, Liu Y, Maurya MR, Benny P, Lassiter C, Li H, et al. The maternal blood lipidome is indicative of the pathogenesis of severe preeclampsia. J Lipid Res. 2021;62:1f118.
Gratacos E. Lipid-mediated endothelial dysfunction: a common factor to preeclampsia and chronic vascular disease. Eur J Obstet Gynecol Reprod Biol. 2000;92:63–6.
Recinella L, Orlando G, Ferrante C, Chiavaroli A, Brunetti L, Leone S. Adipokines: new potential therapeutic target for obesity and metabolic, rheumatic, and cardiovascular diseases. Front Physiol. 2020;11:578966.
Kennedy AJ, Davenport AP. International union of basic and clinical pharmacology CIII: Chemerin receptors CMKLR1 (Chemerin1) and GPR1 (Chemerin2) nomenclature, pharmacology, and function. Pharmacol Rev. 2018;70:174–96.
Tan L, Chen Z, Sun F, Zhou Z, Zhang B, Wang B, et al. Placental trophoblast-specific overexpression of chemerin induces preeclampsia-like symptoms. Clin Sci (Lond). 2022;136:257–72.
Fan X, Ren P, Dhal S, Bejerano G, Goodman SB, Druzin ML, et al. Noninvasive monitoring of placenta-specific transgene expression by bioluminescence imaging. PLoS One. 2011;6:e16f8.
Fan X, Rai A, Kambham N, Sung JF, Singh N, Petitt M, et al. Endometrial VEGF induces placental sFLT1 and leads to pregnancy complications. J Clin Invest. 2014;124:4941–52.
Elmore SA, Cochran RZ, Bolon B, Lubeck B, Mahler B, Sabio D, et al. Histology atlas of the developing mouse placenta. Toxicol Pathol. 2022;50:60–117.
Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem. 1957;226:497–509.
Kelley AS, Puttabyatappa M, Ciarelli JN, Zeng L, Smith YR, Lieberman R, et al. Prenatal testosterone excess disrupts placental function in a sheep model of polycystic ovary syndrome. Endocrinology. 2019;160:2663–72.
Shirai N, Geoly FJ, Bobrowski WF, Okerberg C. The application of Paraphenylenediamine staining for assessment of Phospholipidosis. Toxicol Pathol. 2016;44:1160–5.
Matyash V, Liebisch G, Kurzchalia TV, Shevchenko A, Schwudke D. Lipid extraction by methyl-tert-butyl ether for high-throughput lipidomics. J Lipid Res. 2008;49:1137–46.
Yu S, Fan J, Zhang L, Qin X, Li Z. Assessment of biphasic extraction methods of mouse fecal metabolites for liquid chromatography-mass spectrometry-based Metabolomic studies. J Proteome Res. 2021;20:4487–94.
Welti R, Li W, Li M, Sang Y, Biesiada H, Zhou HE, et al. Profiling membrane lipids in plant stress responses. Role of phospholipase D alpha in freezing-induced lipid changes in Arabidopsis. J Biol Chem. 2002;277:31994–2002.
Buechler C, Feder S, Haberl EM, Aslanidis C. Chemerin Isoforms and Activity in Obesity. Int J Mol Sci. 2019; 20(5):1128
Stepan H, Philipp A, Roth I, Kralisch S, Jank A, Schaarschmidt W, et al. Serum levels of the adipokine chemerin are increased in preeclampsia during and 6 months after pregnancy. Regul Pept. 2011;168:69–72.
Bozaoglu K, Segal D, Shields KA, Cummings N, Curran JE, Comuzzie AG, et al. Chemerin is associated with metabolic syndrome phenotypes in a Mexican-American population. J Clin Endocrinol Metab. 2009;94:3085–8.
Goralski KB, McCarthy TC, Hanniman EA, Zabel BA, Butcher EC, Parlee SD, et al. Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism. J Biol Chem. 2007;282:28175–88.
Ferland DJ, Garver H, Contreras GA, Fink GD, Watts SW. Chemerin contributes to in vivo adipogenesis in a location-specific manner. PLoS One. 2020;15:e0229251.
Helfer G, Wu QF. Chemerin: a multifaceted adipokine involved in metabolic disorders. J Endocrinol. 2018;238:R79–94.
Ernst MC, Issa M, Goralski KB, Sinal CJ. Chemerin exacerbates glucose intolerance in mouse models of obesity and diabetes. Endocrinology. 2010;151:1998–2007.
McIntyre HD, Catalano P, Zhang C, Desoye G, Mathiesen ER, Damm P. Gestational diabetes mellitus. Nat Rev Dis Primers. 2019;5:47.
Bodnar LM, Ness RB, Harger GF, Roberts JM. Inflammation and triglycerides partially mediate the effect of prepregnancy body mass index on the risk of preeclampsia. Am J Epidemiol. 2005;162:1198–206.
Xiao J, Shen F, Xue Q, Chen G, Zeng K, Stone P, et al. Is ethnicity a risk factor for developing preeclampsia? An analysis of the prevalence of preeclampsia in China. J Hum Hypertens. 2014;28:694–8.
Yang A, Zhang H, Sun Y, Wang Y, Yang X, Yang X, et al. Modulation of FABP4 hypomethylation by DNMT1 and its inverse interaction with miR-148a/152 in the placenta of preeclamptic rats and HTR-8 cells. Placenta. 2016;46:49–62.
Inci S, Aksan G, Dogan P. Chemerin as an independent predictor of cardiovascular event risk. Ther Adv Endocrinol Metab. 2016;7:57–68.
Hah YJ, Kim NK, Kim MK, Kim HS, Hur SH, Yoon HJ, et al. Relationship between Chemerin levels and Cardiometabolic parameters and degree of coronary stenosis in Korean patients with coronary artery disease. Diabetes Metab J. 2011;35:248–54.
Smith SA. Peroxisome proliferator-activated receptors and the regulation of mammalian lipid metabolism. Biochem Soc Trans. 2002;30:1086–90.
Stern JH, Rutkowski JM, Scherer PE. Adiponectin, leptin, and fatty acids in the maintenance of metabolic homeostasis through adipose tissue crosstalk. Cell Metab. 2016;23:770–84.
Arrese EL, Saudale FZ, Soulages JL. Lipid droplets as signaling platforms linking metabolic and cellular functions. Lipid Insights. 2014;7:7–16.
Jiao P, Feng B, Li Y, He Q, Xu H. Hepatic ERK activity plays a role in energy metabolism. Mol Cell Endocrinol. 2013;375:157–66.
Wu S-C, Lo Y-M, Lee J-H, Chen C-Y, Chen T-W, Liu H-W, et al. Stomatin modulates adipogenesis through the ERK pathway and regulates fatty acid uptake and lipid droplet growth. Nat Commun. 2022;13:4174.
Scifres CM, Chen B, Nelson DM, Sadovsky Y. Fatty acid binding protein 4 regulates intracellular lipid accumulation in human trophoblasts. J Clin Endocrinol Metab. 2011;96:E1083–91.
Madison BB. Srebp2: a master regulator of sterol and fatty acid synthesis. J Lipid Res. 2016;57:333–5.
Islam MM, Hlushchenko I, Pfisterer SG. Low-density lipoprotein internalization, degradation and receptor recycling along membrane contact sites. Front Cell Dev Biol. 2022;10:826379.
Westerterp M, Tall AR. SORTILIN: many headed hydra. Circ Res. 2015;116:764–6.
Bauer S, Wanninger J, Schmidhofer S, Weigert J, Neumeier M, Dorn C, et al. Sterol regulatory element-binding protein 2 (SREBP2) activation after excess triglyceride storage induces chemerin in hypertrophic adipocytes. Endocrinology. 2011;152:26–35.
Martinez-Reyes I, Chandel NS. Mitochondrial TCA cycle metabolites control physiology and disease. Nat Commun. 2020;11:102.
Wang Y, Yu W, Li S, Guo D, He J, Wang Y. Acetyl-CoA carboxylases and diseases. Front. Oncol. 2022;12:836058.
Permadi W, Mantilidewi KI, Khairani AF, Lantika UA, Ronosulistyo AR, Bayuaji H. Differences in expression of peroxisome proliferator-activated receptor-gamma in early-onset preeclampsia and late-onset preeclampsia. BMC Res Notes. 2020;13:181.
Holdsworth-Carson SJ, Lim R, Mitton A, Whitehead C, Rice GE, Permezel M, et al. Peroxisome proliferator-activated receptors are altered in pathologies of the human placenta: gestational diabetes mellitus, intrauterine growth restriction and preeclampsia. Placenta. 2010;31:222–9.
Caminos JE, Nogueiras R, Gallego R, Bravo S, Tovar S, Garcia-Caballero T, et al. Expression and regulation of adiponectin and receptor in human and rat placenta. J Clin Endocrinol Metab. 2005;90:4276–86.
Nien JK, Mazaki-Tovi S, Romero R, Erez O, Kusanovic JP, Gotsch F, et al. Plasma adiponectin concentrations in non-pregnant, normal and overweight pregnant women. J Perinat Med. 2007;35:522–31.
D'Anna R, Baviera G, Corrado F, Giordano D, De Vivo A, Nicocia G, et al. Adiponectin and insulin resistance in early- and late-onset pre-eclampsia. BJOG. 2006;113:1264–9.
Yan Y, Peng H, Wang P, Wang H, Dong M. Increased expression of fatty acid binding protein 4 in preeclamptic placenta and its relevance to preeclampsia. Placenta. 2016;39:94–100.
Shin JK, Jeong YT, Jo HC, Kang MY, Chang IS, Baek JC, et al. Increased interaction between heat shock protein 27 and mitogen-activated protein kinase (p38 and extracellular signal-regulated kinase) in pre-eclamptic placentas. J Obstet Gynaecol Res. 2009;35:888–94.
Jianhua L, Xueqin M, Jifen H. Expression and clinical significance of LXRalpha and SREBP-1c in placentas of preeclampsia. Open Med (Wars). 2016;11:292–6.
Khaire AA, Thakar SR, Wagh GN, Joshi SR. Placental lipid metabolism in preeclampsia. J Hypertens. 2021;39:127–34.
Garrido-Gomez T, Ona K, Kapidzic M, Gormley M, Simon C, Genbacev O, et al. Severe pre-eclampsia is associated with alterations in cytotrophoblasts of the smooth chorion. Development. 2017;144:767–77.
Staff AC, Ranheim T, Khoury J, Henriksen T. Increased contents of phospholipids, cholesterol, and lipid peroxides in decidua basalis in women with preeclampsia. Am J Obstet Gynecol. 1999;180:587–92.
Huang X, Jain A, Baumann M, Korner M, Surbek D, Butikofer P, et al. Increased placental phospholipid levels in pre-eclamptic pregnancies. Int J Mol Sci. 2013;14:3487–99.
Raijmakers MT, Dechend R, Poston L. Oxidative stress and preeclampsia: rationale for antioxidant clinical trials. Hypertension. 2004;44:374–80.
Rosenson RS, Brewer HB Jr, Ansell BJ, Barter P, Chapman MJ, Heinecke JW, et al. Dysfunctional HDL and atherosclerotic cardiovascular disease. Nat Rev Cardiol. 2016;13:48–60.
Podrez EA. Anti-oxidant properties of high-density lipoprotein and atherosclerosis. Clin Exp Pharmacol Physiol. 2010;37:719–25.
Sevastou I, Kaffe E, Mouratis MA, Aidinis V. Lysoglycerophospholipids in chronic inflammatory disorders: the PLA (2)/LPC and ATX/LPA axes. Biochim Biophys Acta. 2013;1831:42–60.
Yoshioka K, Hirakawa Y, Kurano M, Ube Y, Ono Y, Kojima K, et al. Lysophosphatidylcholine mediates fast decline in kidney function in diabetic kidney disease. Kidney Int. 2022;101:510–26.
Fang ZZ, Tanaka N, Lu D, Jiang CT, Zhang WH, Zhang C, et al. Role of the lipid-regulated NF-kappaB/IL-6/STAT3 axis in alpha-naphthyl isothiocyanate-induced liver injury. Arch Toxicol. 2017;91:2235–44.
Yamamoto Y, Sakurai T, Chen Z, Inoue N, Chiba H, Hui SP. Lysophosphatidylethanolamine affects lipid accumulation and metabolism in a human liver-derived cell line. Nutrients. 2022;14(3):579.
Hisano K, Kawase S, Mimura T, Yoshida H, Yamada H, Haniu H, et al. Structurally different lysophosphatidylethanolamine species stimulate neurite outgrowth in cultured cortical neurons via distinct G-protein-coupled receptors and signaling cascades. Biochem Biophys Res Commun. 2021;534:179–85.
Xu T, Xu X, Zhang L, Zhang K, Wei Q, Zhu L, et al. Lipidomics reveals serum specific lipid alterations in diabetic nephropathy. Front Endocrinol (Lausanne). 2021;12:781417.
Kurano M, Kobayashi T, Sakai E, Tsukamoto K, Yatomi Y. Lysophosphatidylinositol, especially albumin-bound form, induces inflammatory cytokines in macrophages. FASEB J. 2021;35:e21673.
Youssef L, Crovetto F, Simoes RV, Miranda J, Paules C, Blasco M, et al. The interplay between pathophysiological pathways in early-onset severe preeclampsia unveiled by metabolomics. Life (Basel). 2022;12(1):86.
Dunn WB, Brown M, Worton SA, Davies K, Jones RL, Kell DB, et al. The metabolome of human placental tissue: investigation of first trimester tissue and changes related to preeclampsia in late pregnancy. Metabolomics. 2012;8:579–97.
Ichikawa M, Nagamatsu T, Fujii T, Hoya M, Kawai Y, Oda K, et al. Lysophosphatidic acid induces the expression of angiogenic factors in human trophoblast cells –a way of understanding the etiology of PIH. Reprod Immunol Biol. 2015;30:22–31.
Gesta S, Simon MF, Rey A, Sibrac D, Girard A, Lafontan M, et al. Secretion of a lysophospholipase D activity by adipocytes: involvement in lysophosphatidic acid synthesis. J Lipid Res. 2002;43:904–10.
Salgado-Polo F, Fish A, Matsoukas MT, Heidebrecht T, Keune WJ, Perrakis A. Lysophosphatidic acid produced by autotaxin acts as an allosteric modulator of its catalytic efficiency. J Biol Chem. 2018;293:14312–27.