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  1. Nonalcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease and cirrhosis. NAFLD is mediated by changes in lipid metabolism and known risk factors include obesity, metabolic syndrome, ...

    Authors: Yvonne N. Flores, Aryana T. Amoon, Baolong Su, Rafael Velazquez-Cruz, Paula Ramírez-Palacios, Jorge Salmerón, Berenice Rivera-Paredez, Janet S. Sinsheimer, Aldons J. Lusis, Adriana Huertas-Vazquez, Sammy Saab, Beth A. Glenn, Folasade P. May, Kevin J. Williams, Roshan Bastani and Steven J. Bensinger
    Citation: Lipids in Health and Disease 2021 20:136
    Content type: Research Published on:

  2. Dysregulated lipid metabolism is critically involved in the development of hepatocellular carcinoma (HCC). The respective metabolic pathways affected in HCC can be identified using suitable experimental models...

    Authors: Elisabeth M. Haberl, Rebekka Pohl, Lisa Rein-Fischboeck, Marcus Höring, Sabrina Krautbauer, Gerhard Liebisch and Christa Buechler
    Citation: Lipids in Health and Disease 2021 20:135
    Content type: Research Published on:

  3. Conicity index, body-shape index, lipid accumulation product (LAP), waist circumference (WC), triglyceride, triglyceride-glucose (TyG) index, hepatic steatosis index (HSI), waist-to-height ratio (WHtR), TyG in...

    Authors: Guotai Sheng, Song Lu, Qiyang Xie, Nan Peng, Maobin Kuang and Yang Zou
    Citation: Lipids in Health and Disease 2021 20:134
    Content type: Research Published on:

  4. Limited studies regarding the correlation of lipid accumulation product (LAP) with a decreased estimated glomerular filtration rate (eGFR) have yielded conflicting findings, and no report has demonstrated the ...

    Authors: Pijun Yan, Yong Xu, Ying Miao, Qian Tang, Yuru Wu, Xue Bai, Zhihong Zhang, Qian Li and Qin Wan
    Citation: Lipids in Health and Disease 2021 20:131
    Content type: Research Published on:

  5. High serum Lipoprotein(a) (Lp(a)) level and Apolipoprotein B/Apolipoprotein AΙ (ApoB/ApoA-Ι) ratio are risk factors for cardiovascular disease and kidney disease and have been found to be correlated with the p...

    Authors: Jun Tao, Wen Dai, Chenglin Ye, Qian Yao, Man Zhou and Yan Li
    Citation: Lipids in Health and Disease 2021 20:130
    Content type: Research Published on:

  6. Mycobacterium tuberculosis (Mtb), the main etiology of tuberculosis (TB), is predominantly an intracellular pathogen that has caused infection, disease and death in humans for centuries. Lipid droplets (LDs) are ...

    Authors: Daniel Mekonnen, Awoke Derbie, Adane Mihret, Solomon Abebe Yimer, Tone Tønjum, Baye Gelaw, Endalkachew Nibret, Abaineh Munshae, Simon J. Waddell and Abraham Aseffa
    Citation: Lipids in Health and Disease 2021 20:129
    Content type: Review Published on:

  7. Evidence suggests that proteins related to lipid metabolism, such as apolipoproteins, play an important role in the maintenance of normal vision. While several members of the apolipoprotein family are abundant...

    Authors: Parth A. Patel, Tae Jin Lee, Sai Karthik Kodeboyina, Garrett Jones, Kathryn Bollinger, Lane Ulrich, David Bogorad, Amy Estes, Wenbo Zhi, Shruti Sharma and Ashok Sharma
    Citation: Lipids in Health and Disease 2021 20:128
    Content type: Research Published on:

  8. Coronary artery disease (CAD) is a common cardiovascular disease, and abnormal blood lipid metabolism is an important risk factor. Transforming growth factor-ß (TGF-ß) and its receptor (TGF-ßR) can inhibit the...

    Authors: Haibin Chen, Yiping Wang, Bing Sun, Xunxia Bao, Yu Tang, Feifei Huang, Sibo Zhu and Jiahong Xu
    Citation: Lipids in Health and Disease 2021 20:127
    Content type: Research Published on:

  9. The coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). At present, the COVID-19 has been prevalent worldwide for more than a year and caused...

    Authors: Yanlan Xu, Xinyu Yang, Hua Bian and Mingfeng Xia
    Citation: Lipids in Health and Disease 2021 20:126
    Content type: Review Published on:

  10. Abnormalities in serum lipids and lipoproteins have been documented to link to the risk of cancers in recent years, but its prognostic value for cancer is not known. This study retrospectively evaluated the si...

    Authors: Cong Ma, Xiaoyan Wang, Jingjing Guo and Ping Liu
    Citation: Lipids in Health and Disease 2021 20:69
    Content type: Research Published on:

  11. Research on dyslipidemia during pregnancy in women with gestational diabetes mellitus (GDM) has rarely been conducted in Asia. The present study aimed to evaluate maternal mid-trimester lipid profile in relati...

    Authors: Yuan Li, Xiaoqian Wang, Fengjuan Jiang, Wenqing Chen, Jie Li and Xiaotian Chen
    Citation: Lipids in Health and Disease 2021 20:125
    Content type: Research Published on:

  12. Large observational studies have shown that small, dense LDL subfractions are related to atherosclerotic cardiovascular disease. This study assessed the effects of two highly effective lipid-lowering therapies...

    Authors: Leticia C. S. Pinto, Ana P. Q. Mello, Maria C. O. Izar, Nagila R. T. Damasceno, Antonio M. F. Neto, Carolina N. França, Adriano Caixeta, Henrique T. Bianco, Rui M. S. Póvoa, Flavio T. Moreira, Amanda S. F. Bacchin and Francisco A. Fonseca
    Citation: Lipids in Health and Disease 2021 20:124
    Content type: Research Published on:

  13. The relationship between the APOE gene polymorphism and lipid profiles and atrial fibrillation (AF) remains controversial. The current study purposed to investigate how the APOE gene SNPs (rs429358 and rs7412) an...

    Authors: Xunwei Deng, Jingyuan Hou, Qiaoting Deng and Zhixiong Zhong
    Citation: Lipids in Health and Disease 2021 20:123
    Content type: Research Published on:

  14. Idiopathic membranous nephropathy (IMN) may have various clinical outcomes. Hyperlipidemia is quite common in IMN. However, the utility of the lipid profile in predicting outcomes remains unknown. This study a...

    Authors: Lei Dong, Wang Wei, Min Han and Gang Xu
    Citation: Lipids in Health and Disease 2021 20:122
    Content type: Research Published on:

  15. Current studies support lipid ratios [the total cholesterol (TC)/high-density lipoprotein cholesterol (HDL-C) ratio; the triglyceride (TG)/HDL-C ratio; the low-density lipoprotein cholesterol (LDL -C)/HDL-C ra...

    Authors: Yu Yu, Tian Lan, Dandan Wang, Wangsheng Fang, Yu Tao, Minghui Li, Xiao Huang, Wei Zhou, Tao Wang, Lingjuan Zhu, Huihui Bao and Xiaoshu Cheng
    Citation: Lipids in Health and Disease 2021 20:121
    Content type: Research Published on:

  16. Life expectancy has greatly increased, generating an improvement in screening programs for disease prevention, lifesaving drugs and medical devices. The impact of lowering low-density lipoprotein cholesterol (...

    Authors: Yehudit Eden Friedman, David M. Steinberg, Michal Canetti, Ido Cohen, Shlomo Segev and Ophira Salomon
    Citation: Lipids in Health and Disease 2021 20:120
    Content type: Research Published on:

  17. Blood lipid increases during gestation are considered a physiological adaption, and decrease after delivery. However, some adverse pregnancy outcomes are thought to be related to gestational lipid levels. Ther...

    Authors: Yandi Zhu, Haiyan Zhu, Qinyu Dang, Qian Yang, Dongxu Huang, Yadi Zhang, Xiaxia Cai and Huanling Yu
    Citation: Lipids in Health and Disease 2021 20:119
    Content type: Research Published on:

  18. The present study was aimed to establish a prediction model for in-stent restenosis (ISR) in subjects who had undergone percutaneous coronary intervention (PCI) with drug-eluting stents (DESs).

    Authors: Min-Tao Gai, Bing Zhu, Xiao-Cui Chen, Fen Liu, Xiang Xie, Xiao-Ming Gao, Xiang Ma, Zhen-Yan Fu, Yi-Tong Ma and Bang-dang Chen
    Citation: Lipids in Health and Disease 2021 20:118
    Content type: Research Published on:

  19. Angiopoietin-like proteins (ANGPTL), primarily 3, 4, and 8, play a major role in maintaining energy homeostasis by regulating triglyceride metabolism. This study evaluated the level of ANGPTL3, 4, and 8 in the...

    Authors: Hossein Arefanian, Irina Al-Khairi, Nermeen Abu Khalaf, Preethi Cherian, Sina Kavalakatt, Dhanya Madhu, Aditi Mathur, Mohamed G. Qaddoumi, Fahd Al-Mulla, Jehad Abubaker and Mohamed Abu-Farha
    Citation: Lipids in Health and Disease 2021 20:117
    Content type: Research Published on:

  20. Dyslipidemia is a predisposing factor for coronary heart disease (CHD). High-intensity statin therapy is recommended as secondary prevention. ABCB1 and SLCO1B1 genes influence the efficacy and safety of statin...

    Authors: Tingting Wang, Li Sun, Li Xu, Ting Zhao, Jie Feng, Luhai Yu, Jianhua Wu and Hongjian Li
    Citation: Lipids in Health and Disease 2021 20:116
    Content type: Research Published on:

  21. Cancer-associated cachexia (CAC) is a metabolic syndrome characterized by progressive depletion of adipose and muscle tissue that cannot be corrected by conventional nutritional therapy. Adipose tissue, an imp...

    Authors: Diya Sun, Zuoyou Ding, Lei Shen, Fan Yang, Jun Han and Guohao Wu
    Citation: Lipids in Health and Disease 2021 20:115
    Content type: Research Published on:

  22. Previous epidemiological studies have indicated the seasonal variability of serum lipid levels. However, little research has explicitly examined the separate secular and seasonal trends of dyslipidemia. The pr...

    Authors: Jiahui Lao, Yafei Liu, Yang Yang, Peng Peng, Feifei Ma, Shuang Ji, Yujiao Chen and Fang Tang
    Citation: Lipids in Health and Disease 2021 20:114
    Content type: Research Published on:

  23. Hypertriglyceridemia has emerged as a critical coronary artery disease (CAD) risk factor. Rare loss-of-function (LoF) variants in apolipoprotein C-III have been reported to reduce triglycerides (TG) and are ca...

    Authors: Shiwali Goyal, Yosuke Tanigawa, Weihua Zhang, Jin-Fang Chai, Marcio Almeida, Xueling Sim, Megan Lerner, Juliane Chainakul, Jonathan Garcia Ramiu, Chanel Seraphin, Blair Apple, April Vaughan, James Muniu, Juan Peralta, Donna M. Lehman, Sarju Ralhan…
    Citation: Lipids in Health and Disease 2021 20:113
    Content type: Research Published on:

  24. Increased physical activity is inversely related to the risk to develop cardiovascular disease (CVD). In a recent systematic review, it was reported that CVD patients had an increased cholesterol absorption an...

    Authors: S. Mashnafi, J. Plat, R. P. Mensink, P. J. Joris, J. P. D. Kleinloog and S. Baumgartner
    Citation: Lipids in Health and Disease 2021 20:112
    Content type: Research Published on:

  25. Limited data are available for validation of low-density lipoprotein cholesterol (LDL) calculation (LDLcal) in the adult Korean population. The aim of this study was to develop and validate a new equation for LDL

    Authors: Rihwa Choi, Mi-Jung Park, Youngju Oh, Sung Ho Kim, Sang Gon Lee and Eun Hee Lee
    Citation: Lipids in Health and Disease 2021 20:111
    Content type: Research Published on:

  26. Previous studies show that abnormal lipoprotein metabolism can increase the prevalence of chronic kidney disease (CKD). This study prospectively investigated the association of triglycerides to high-density li...

    Authors: Shiqi Lv, Han Zhang, Jing Chen, Ziyan Shen, Cheng Zhu, Yulu Gu, Xixi Yu, Di Zhang, Yulin Wang, Xiaoqiang Ding and Xiaoyan Zhang
    Citation: Lipids in Health and Disease 2021 20:110
    Content type: Research Published on:

  27. Cancer patients often exhibit chemotherapy-associated changes in serum lipid profiles, however, their prognostic value before and after adjuvant chemotherapy on survival among non-small-cell lung cancer (NSCLC...

    Authors: Fan Luo, Kang-mei Zeng, Jia-xin Cao, Ting Zhou, Su-xia Lin, Wen-juan Ma, Yun-peng Yang, Zhong-han Zhang, Fei-teng Lu, Yan Huang, Hong-yun Zhao and Li Zhang
    Citation: Lipids in Health and Disease 2021 20:109
    Content type: Research Published on:

  28. The current study was conducted to explore the effects of chemerin and homocysteine (Hcy) levels and their associations with the occurrence and development of ischemic cerebrovascular disease (ICVD).

    Authors: Lixuan Wang, Jianpu Jia, Zhen Hong, Leguo Zhang and Junling Zhang
    Citation: Lipids in Health and Disease 2021 20:108
    Content type: Research Published on:

  29. Dyslipidemia is a feature of impaired metabolic health in conjunction with impaired glucose metabolism and central obesity. However, the contribution of factors to postprandial lipemia in healthy but metabolic...

    Authors: Stephanie M. Wilson, Adam P. Maes, Carl J. Yeoman, Seth T. Walk and Mary P. Miles
    Citation: Lipids in Health and Disease 2021 20:107
    Content type: Research Published on:

  30. Proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitors have been demonstrated to produce significantly greater reduction in LDL cholesterol levels and cardiovascular events than standard statin thera...

    Authors: Fei Gao, Zhi Jian Wang, Xiao Teng Ma, Hua Shen, Li Xia Yang and Yu Jie Zhou
    Citation: Lipids in Health and Disease 2021 20:106
    Content type: Research Published on:

  31. Low-density lipoprotein cholesterol (LDL-C) independently impacts aging-related health outcomes and plays a critical role in cardiovascular diseases (CVDs). However, there are limited predictive data on all-ca...

    Authors: Ryuichi Kawamoto, Asuka Kikuchi, Taichi Akase, Daisuke Ninomiya and Teru Kumagi
    Citation: Lipids in Health and Disease 2021 20:105
    Content type: Research Published on:

  32. Colorectal cancer (CRC) is a malignancy of the large intestine, whose development and prognosis have been demonstrated to be associated with altered lipid metabolism. High cholesterol intake is associated with...

    Authors: Ryuk Jun Kwon, Eun-Ju Park, Sang Yeoup Lee, Youngin Lee, Chungsu Hwang, Choongrak Kim and Young Hye Cho
    Citation: Lipids in Health and Disease 2021 20:104
    Content type: Research Published on:

  33. Low-density lipoprotein cholesterol (LDL-C) metabolic disorder is common in individuals with diabetes. The role of LDL-C in mild cognitive impairment (MCI) remains to be explored. We aim to investigate the ass...

    Authors: Haoqiang Zhang, Wenwen Zhu, Tong Niu, Zheng Wang, Ke An, Wuyou Cao, Jijing Shi and Shaohua Wang
    Citation: Lipids in Health and Disease 2021 20:103
    Content type: Research Published on:

  34. Canola oil (Can) and several vegetable oils shorten the lifespan of stroke-prone spontaneously hypertensive rats (SHRSP). Although similar lifespan shortening has been reported for partially hydrogenated Can, ...

    Authors: Kenjiro Tatematsu, Daisuke Miyazawa, Yoshiaki Saito, Harumi Okuyama and Naoki Ohara
    Citation: Lipids in Health and Disease 2021 20:102
    Content type: Research Published on:

  35. As an autosomal dominant disorder, familial hypercholesterolemia (FH) is mainly attributed to disease-causing variants in the low-density lipoprotein receptor (LDLR) gene. The aim of this study was to explore the...

    Authors: Haochang Hu, Ruoyu Chen, Yingchu Hu, Jian Wang, Shaoyi Lin and Xiaomin Chen
    Citation: Lipids in Health and Disease 2021 20:101
    Content type: Research Published on:

  36. The deleterious effect of maternal high-fat diet (HFD) on the fetal rat liver may cause later development of non-alcoholic fatty liver disease (NAFLD). The aim of this study was to evaluate the effect of mater...

    Authors: Szu-Wei Huang, Yu-Che Ou, Kuo-Shu Tang, Hong-Ren Yu, Li-Tung Huang, You-Lin Tain, I-Chun Lin, Jiunn-Ming Sheen, Chih-Yao Hou, Ching-Chou Tsai and Mao-Meng Tiao
    Citation: Lipids in Health and Disease 2021 20:100
    Content type: Research Published on:

  37. Triglyceride glucose-body mass index (TyG-BMI) has been proven to be a reliable substitute for insulin resistance. However, whether a causal association exists between TyG-BMI and new-onset diabetes remains un...

    Authors: Xiaoyu Wang, Jingdong Liu, Zongyou Cheng, Yanjia Zhong, Xiaohua Chen and Wei Song
    Citation: Lipids in Health and Disease 2021 20:99
    Content type: Research Published on:

  38. The incidence of severe (S-HTG) and very severe hypertriglyceridemia (VS-HTG) among Canadians is unknown. This study aimed to determine the incidence, characteristics, predictors and care patterns for individu...

    Authors: Amanda J. Berberich, Alexandra M. Ouédraogo, Salimah Z. Shariff, Robert A. Hegele and Kristin K. Clemens
    Citation: Lipids in Health and Disease 2021 20:98
    Content type: Research Published on:

  39. Pancreaticobiliary reflux (PBR) causes chronic inflammation of the gallbladder mucosa and changes in the bile components, which are known to promote gallstone formation. This study aimed to investigate the bil...

    Authors: Yukai Xiang, Xiangyu Kong, Cheng Zhang, Chuanqi He, Jingli Cai, Ruiqi Lu, Bosen Zhang, Liu Lu and Yulong Yang
    Citation: Lipids in Health and Disease 2021 20:97
    Content type: Research Published on:

  40. Maresin-1 (MaR1) is an anti-inflammatory pro-resolving mediator and is considered a potential regulator of metabolic diseases. Non-alcoholic fatty liver disease (NAFLD) is a very common metabolic liver disease...

    Authors: Xia Fang, Hongya Wang, Ting Ye, Xiaolan Fu, Xiaozhen Tan, Yan Zeng, Jiahao Fan and Yong Xu
    Citation: Lipids in Health and Disease 2021 20:96
    Content type: Research Published on:

  42. Intraductal papillary mucinous neoplasms (IPMNs) can potentially undergo malignant transformation. Studies have shown that high-density lipoprotein cholesterol (HDL-c) was associated with the risk of cancer. I...

    Authors: Cheng Wang, Tingting Lin, Xinru Wang, Zhicheng Yu, Xiaoling Zhuge, Wenjing Cui, Miaomiao Wang, Zhongqiu Wang, Chuangen Guo and Xiao Chen
    Citation: Lipids in Health and Disease 2021 20:94
    Content type: Research Published on:

  43. About 20–40 % of autistic people experience a phenomenon of regression. Retinol binding protein 4 (RBP4) plays an important role as an inflammatory neurotrophic adipokine and is a promising mediator of the fat...

    Authors: Jianling Chen, Jing Chen, Yun Xu, Peipei Cheng, Shunying Yu, Yingmei Fu and Yasong Du
    Citation: Lipids in Health and Disease 2021 20:93
    Content type: Research Published on:

  44. Non-alcoholic fatty liver disease (NAFLD) is a multifactorial condition associated with aging, insulin resistance, metabolic syndrome, genetic factors and more. Although genetic traits are among the most impor...

    Authors: Li-jie Chen, Jing Guo, Song-xia Zhang, Ying Xu, Qing Zhao, Wei Zhang, Jian Xiao and Yao Chen
    Citation: Lipids in Health and Disease 2021 20:92
    Content type: Research Published on:

  45. It is unknown whether early postpartum abnormal glucose metabolism (AGM) in women with previous gestational diabetes mellitus (GDM) is related to their mid-trimester lipid profile. The aim of this study was to...

    Authors: Fenghua Lai, Zeting Li, Shufan Yue, Ling Pei, Huangmeng Xiao, Zhuyu Li, Yanbing Li, Haipeng Xiao and Xiaopei Cao
    Citation: Lipids in Health and Disease 2021 20:91
    Content type: Research Published on:

  47. Retinol binding protein 4 (RBP4) has been proposed to play a role in the pathophysiology of coronary artery disease (CAD), but previous findings on the association of RBP4 levels with CAD are inconsistent.

    Authors: Hengying Chen, Jiaying Zhang, Jiayu Lai, Yingyu Zhou, Xiaoping Lin, Guifang Deng, Zheqing Zhang and Liping Li
    Citation: Lipids in Health and Disease 2021 20:89
    Content type: Review Published on:

  48. Coronary artery disease (CAD) is considered as a multi-faceted chronic inflammatory disease involving reduced blood supply to the myocardium as a result of accumulating lipids in the atrial walls. Visceral adi...

    Authors: Nariman Moradi, Fatima Zahraa Fouani, Akram Vatannejad, Abbas Bakhti Arani, Soraya Shahrzad and Reza Fadaei
    Citation: Lipids in Health and Disease 2021 20:88
    Content type: Research Published on:

  49. Psoriasis is a chronic, immune-mediated inflammatory skin disease characterized by abnormal T cell activation and excessive proliferation of keratinocytes. In addition to skin manifestations, psoriasis has bee...

    Authors: Bai Ruiyang, Adriana Panayi, Wu Ruifang, Zhang Peng and Fu Siqi
    Citation: Lipids in Health and Disease 2021 20:87
    Content type: Review Published on:
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Lipids in Health and Disease

ISSN: 1476-511X