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  1. Some patients administered cholesterol-lowering therapies may experience an increase in the proportion of small LDL particles, which may be misinterpreted as a worsening of atherosclerotic coronary heart disea...

    Authors: Harold Bays, Scott Conard, Lawrence A Leiter, Steven Bird, Erin Jensen, Mary E Hanson, Arvind Shah and Andrew M Tershakovec
    Citation: Lipids in Health and Disease 2010 9:136
    Content type: Research Published on:

  2. PUFAs are potent inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, an enzyme catalyzing the conversion of HMGCoA to mevalonate, the rate limiting step in cholesterol biosynthesis. Statin...

    Authors: Maria Notarnicola, Caterina Messa, Maria G Refolo, Valeria Tutino, Angelica Miccolis and Maria G Caruso
    Citation: Lipids in Health and Disease 2010 9:135
    Content type: Research Published on:

  3. Kurozu concentrated liquid (KCL) is used as a health-promoting supplement for the treatment of disorders such as cancer, hyperlipidemia, and hypertension in Japan. We investigated the possible anti-obesity eff...

    Authors: Li-Tao Tong, Yoshinori Katakura, Sayaka Kawamura, Sanae Baba, Yasutake Tanaka, Miyako Udono, Yoshie Kondo, Kumi Nakamura, Katsumi Imaizumi and Masao Sato
    Citation: Lipids in Health and Disease 2010 9:134
    Content type: Research Published on:

  4. Despite significant improvements in the treatment of coronary heart disease (CHD), it is still a major cause of mortality and morbidity among the Iranian population. Epidemiological studies have documented tha...

    Authors: Teymoor Yary, Kourosh Soleimannejad, Firdaus Abd Rahim, Mirnalini Kandiah, Sanaz Aazami, Seyedehozma Jafar Poor, Wong Teck Wee and Golnaz Aazami
    Citation: Lipids in Health and Disease 2010 9:133
    Content type: Research Published on:

  5. 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) catalyzes the conversion of inactive glucocorticoids to active glucocorticoids and plays an important role in the development of obesity and metabolic syndrom...

    Authors: Sakamuri SS Vara Prasad, Anamthathmakula Prashanth, Chodavarapu Pavan Kumar, Sirisha J Reddy, Nappan V Giridharan and Ayyalasomayajula Vajreswari
    Citation: Lipids in Health and Disease 2010 9:132
    Content type: Short paper Published on:

  6. It is designed to investigate the effects of combination therapy of allicin and fenofibrate on the endothelial and liver functions in rats with hyperlipidemia.

    Authors: Weihong Li, Daxin Wang, Guohua Song, Chunxia Zuo, Xianfu Qiao and Shucun Qin
    Citation: Lipids in Health and Disease 2010 9:131
    Content type: Research Published on:

  7. The high incidence of insulin resistance and the metabolic syndrome in South Asians remains unexplained. I propose that a defect in the activity of Δ6 and Δ5 desaturases and consequent low plasma and tissue conce...

    Authors: Undurti N Das
    Citation: Lipids in Health and Disease 2010 9:130
    Content type: Hypothesis Published on:

  8. Dysregulated inflammation in cystic fibrosis (CF) is attributed to an altered production of inflammatory mediators derived from polyunsaturated lipids. In comparison to the arachidonic acid (AA) cascade, littl...

    Authors: Elena Bravo, Mariarosaria Napolitano, Sara Benedetti Valentini and Serena Quattrucci
    Citation: Lipids in Health and Disease 2010 9:129
    Content type: Short paper Published on:

  9. Cardiovascular diseases (CVD) are the main cause of death and disability in developed countries. In most cases, the progress of CVD is influenced by environmental factors and multifactorial inheritance. The pu...

    Authors: Rafael O Alvim, Silvia RS Freitas, Noely E Ferreira, Paulo CJL Santos, Roberto S Cunha, José G Mill, José E Krieger and Alexandre C Pereira
    Citation: Lipids in Health and Disease 2010 9:128
    Content type: Research Published on:

  10. This post-hoc analysis compared the lipid-altering efficacy of Ezetimibe/Simvastatin 10/20 mg (EZ/Simva) versus Rosuvastatin 10 mg (Rosuva) in patients stratified by statin potency/dose prior to randomization.

    Authors: Margus Viigimaa, Helena Vaverkova, Michel Farnier, Maurizio Averna, Luc Missault, Mary E Hanson, Qian Dong, Arvind Shah and Philippe Brudi
    Citation: Lipids in Health and Disease 2010 9:127
    Content type: Research Published on:

  11. Conjugated linoleic acids (CLA) are a group of positional and geometric isomers of linoleic acid with proven beneficial influence on health. They show e.g. anticarcinogenic, antiobesity, and antiatherogenic ef...

    Authors: Agnieszka Białek, Andrzej Tokarz, Agnieszka Dudek, Weronika Kazimierska and Wojciech Bielecki
    Citation: Lipids in Health and Disease 2010 9:126
    Content type: Research Published on:

  12. Sleep deprivation has been shown to increase inflammatory markers in rat sera and peripheral blood mononuclear cells. Inflammation is a condition associated with pathologies such as obesity, cancer, and cardio...

    Authors: José C Rosa Neto, Fábio S Lira, Daniel P Venancio, Cláudio A Cunha, Lila M Oyama, Gustavo D Pimentel, Sérgio Tufik, Cláudia M Oller do Nascimento, Ronaldo VT Santos and Marco T de Mello
    Citation: Lipids in Health and Disease 2010 9:125
    Content type: Research Published on:

  13. Heme oxygenase-1 (HO-1), the rate-limiting enzyme in heme catabolism, has been reported to have potential antioxidant properties. However, the role of HO-1 on hepatocyte apoptosis remains unclear. We aim to el...

    Authors: YueMin Nan, RongQi Wang, SuXian Zhao, Fang Han, Wen Juan Wu, LingBo Kong, Na Fu, Li Kong and Jun Yu
    Citation: Lipids in Health and Disease 2010 9:124
    Content type: Research Published on:

  14. The association of methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and serum lipid profiles is still controversial in diverse ethnics. Bai Ku Yao is an isolated subgroup of the Yao minority in Ch...

    Authors: Lin Zhang, Rui-Xing Yin, Wan-Ying Liu, Lin Miao, Dong-Feng Wu, Lynn Htet Htet Aung, Xi-Jiang Hu, Xiao-Li Cao, Jin-Zhen Wu and Shang-Ling Pan
    Citation: Lipids in Health and Disease 2010 9:123
    Content type: Research Published on:

  15. The association between modulation of detailed lipoprotein profiles and cholesterol ester transfer (CET) activity by peroxisome proliferator-activated receptor (PPAR)-a agonists in patients with coronary arter...

    Authors: Tetsuro Miyazaki, Kazunori Shimada, Katsumi Miyauchi, Atsumi Kume, Kosei Tanimoto, Takashi Kiyanagi, Katsuhiko Sumiyoshi, Makoto Hiki, Hiroshi Mokuno, Shinya Okazaki, Hitoshi Sato, Takeshi Kurata and Hiroyuki Daida
    Citation: Lipids in Health and Disease 2010 9:122
    Content type: Research Published on:

  16. Intermittent hypoxia (IH), a model of sleep apnea, produces weight loss in animals. We hypothesized that changes in brown adipose tissue (BAT) function are involved in such phenomenon. We investigated the effe...

    Authors: Denis Martinez, Cintia Z Fiori, Diego Baronio, Alicia Carissimi, Renata SR Kaminski, Lenise J Kim, Darlan P Rosa and Ângelo Bos
    Citation: Lipids in Health and Disease 2010 9:121
    Content type: Research Published on:

  17. To investigate the effect of oxidized low density lipoprotein receptor-1 (LOX-1) on tubular epithelial-mesenchymal transition (TEMT) induced by oxidized low-density lipoprotein (ox-LDL) and its mechanism.

    Authors: Rui Wang, Guohua Ding, Wei Liang, Cheng Chen and Hongxia Yang
    Citation: Lipids in Health and Disease 2010 9:120
    Content type: Short paper Published on:

  18. The double-blinded placebo-controlled randomized study has been performed in 51 coronary heart disease (CHD) patients to estimate the effects of time-released garlic powder tablets Allicor on the values of 10-...

    Authors: Igor A Sobenin, Valentin V Pryanishnikov, Lyudmila M Kunnova, Yevgeny A Rabinovich, Danik M Martirosyan and Alexander N Orekhov
    Citation: Lipids in Health and Disease 2010 9:119
    Content type: Research Published on:

  20. Atherosclerosis is considered a chronic inflammatory disease in which monocytes and macrophages are critical. These cells express CD14, toll-like receptor (TLR) 2, and TLR4 on their surfaces, are activated by ...

    Authors: Luis Chávez-Sánchez, Karina Chávez-Rueda, Maria Victoria Legorreta-Haquet, Edgar Zenteno, Yadira Ledesma-Soto, Eduardo Montoya-Díaz, Emiliano Tesoro-Cruz, Alejandra Madrid-Miller and Francisco Blanco-Favela
    Citation: Lipids in Health and Disease 2010 9:117
    Content type: Research Published on:

  21. This study aimed to analyze the effects of exercise at the aerobic/anaerobic transition on the markers of non-alcoholic fatty liver disease (NAFLD), insulin sensitivity and the blood chemistry of rats kept on ...

    Authors: José D Botezelli, Rodrigo F Mora, Rodrigo A Dalia, Leandro P Moura, Lucieli T Cambri, Ana C Ghezzi, Fabrício A Voltarelli and Maria AR Mello
    Citation: Lipids in Health and Disease 2010 9:116
    Content type: Research Published on:

  22. Prevalence of dyslipidemia is high and increases even in younger people. The key aim of this study was to explore the group characteristics of patients in different durations of dyslipidemia and provide clues ...

    Authors: Yingying Liu, Puhong Zhang, Wei Wang, Huan Wang, Ling Zhang, Wei Wu and Xiuhua Guo
    Citation: Lipids in Health and Disease 2010 9:115
    Content type: Research Published on:

  23. Tree shrew and beijing duck are regarded as animal models resistant to atherosclerosis (AS). This study was carried out to discover the potential mechanism.

    Authors: Hui-rong Liu, Gang Wu, Bing Zhou and Bao-sheng Chen
    Citation: Lipids in Health and Disease 2010 9:114
    Content type: Research Published on:

  25. Nutritional factors play a major role in cancer initiation and development. Dietary polyunsaturated fatty acids (PUFAs) have the ability to induce modifications in the activity of lipoxygenase (LOX) and cycloo...

    Authors: Andrea Comba, Damian M Maestri, María A Berra, Carolina Paola Garcia, Undurti N Das, Aldo R Eynard and María E Pasqualini
    Citation: Lipids in Health and Disease 2010 9:112
    Content type: Research Published on:

  26. The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) amplifies intracellular glucocorticoid action by converting inactive glucocorticoids to their active forms in vivo. Adipose-specific overexpression of...

    Authors: Sakamuri SS Vara Prasad, Shanmugam S Jeya Kumar, Putcha Uday Kumar, Syed SYH Qadri and Ayyalasomayajula Vajreswari
    Citation: Lipids in Health and Disease 2010 9:111
    Content type: Short paper Published on:

  27. Endothelial lipase (EL) is a major determinant of high-density lipoprotein-cholesterol (HDL-C) metabolism, but the association of endothelial lipase gene (LIPG) polymorphism and serum HDL-C levels is scarce and c...

    Authors: Wan-Ying Liu, Rui-Xing Yin, Lin Zhang, Xiao-Li Cao, Lin Miao, Dong-Feng Wu, Lynn Htet Htet Aung, Xi-Jiang Hu, Wei-Xiong Lin and De-Zhai Yang
    Citation: Lipids in Health and Disease 2010 9:110
    Content type: Research Published on:

  28. Cytokines (IL-6, IL-10 and TNF-α) are increased after exhaustive exercise in the rat retroperitoneal (RPAT) and mesenteric adipose tissue (MEAT) pads. On the other hand, these cytokines show decreased expressi...

    Authors: Fábio S Lira, José C Rosa, Gustavo D Pimentel, Victor AF Tarini, Ricardo M Arida, Flávio Faloppa, Eduardo S Alves, Cláudia O do Nascimento, Lila M Oyama, Marília Seelaender, Marco T de Mello and Ronaldo VT Santos
    Citation: Lipids in Health and Disease 2010 9:109
    Content type: Research Published on:

  31. Some polyunsaturated fatty acids (PUFAs), if not all, have been shown to have tumoricidal action, but their exact mechanism(s) of action is not clear. In the present study, we observed that n-6 PUFA linoleic a...

    Authors: Xiaofeng Lu, Haining Yu, Qi Ma, Shengrong Shen and Undurti N Das
    Citation: Lipids in Health and Disease 2010 9:106
    Content type: Research Published on:

  32. Polyunsaturated fatty acids are essential nutrients for humans. They are structural and functional components of cell membranes and pre-stages of the hormonally and immunologically active eicosanoids. Recent d...

    Authors: Michael Huss, Andreas Völp and Manuela Stauss-Grabo
    Citation: Lipids in Health and Disease 2010 9:105
    Content type: Research Published on:

  34. Oxidized lipoproteins play important roles in the atherosclerotic processes. Oxidized lipoprotein(a) (oxLp(a)) may be more potent in atherosclerotic pathophysiology than native Lp(a), a cardiovascular disease-...

    Authors: Kazuhiko Kotani, Shingo Yamada, Shuumarjav Uurtuya, Toshiyuki Yamada, Nobuyuki Taniguchi and Ikunosuke Sakurabayashi
    Citation: Lipids in Health and Disease 2010 9:103
    Content type: Short paper Published on:

  35. It has been well documented that apolipoprotein M (apoM) is principally expressed in the liver and kidney. However we found that there was weak apoM expression in other tissues or organs too, which could not b...

    Authors: Guanghua Luo, Xiaoying Zhang, Qinfeng Mu, Lujun Chen, Lu Zheng, Jiang Wei, Maria Berggren-Söderlund, Peter Nilsson-Ehle and Ning Xu
    Citation: Lipids in Health and Disease 2010 9:102
    Content type: Research Published on:

  36. Fish oil is known to improve lifestyle-related diseases. These effects occur partly via activation of PPARs by the n-3 polyunsaturated fatty acids included abundantly in fish oil. We investigated fish oil func...

    Authors: Masaki Wakutsu, Nobuyo Tsunoda, Sachiko Shiba, Etsuko Muraki and Keizo Kasono
    Citation: Lipids in Health and Disease 2010 9:101
    Content type: Research Published on:

  37. The body mass index (BMI) is the most commonly used marker for evaluating obesity related risks, however, central obesity measures have been proposed to be more informative. Lipid accumulation product (LAP) is...

    Authors: Mohammadreza Bozorgmanesh, Farzad Hadaegh and Fereidoun Azizi
    Citation: Lipids in Health and Disease 2010 9:100
    Content type: Research Published on:

  38. The Berlin Fat Mouse Inbred (BFMI) line is a new mouse model for obesity, which was long-term selected for high fatness. Peroxisome proliferator-activated receptors (PPARs) are involved in the control of energ...

    Authors: Asja Wagener, Helge F Goessling, Armin O Schmitt, Susanne Mauel, Achim D Gruber, Richard Reinhardt and Gudrun A Brockmann
    Citation: Lipids in Health and Disease 2010 9:99
    Content type: Research Published on:

  39. Docosahexaenoic acid (DHA, 22:6ω3) is a fundamental component of cell membranes, especially in the brain and retina. In the experimental animal, DHA deficiency leads to suboptimal neurological performance and ...

    Authors: Manuela Martinez, Natalia Ichaso, Fernando Setien, Nuria Durany, Xiao Qiu and William Roesler
    Citation: Lipids in Health and Disease 2010 9:98
    Content type: Research Published on:

  41. Low level of high density lipoprotein cholesterol (HDL-C) has high prevalence in the Tehran Lipid and Glucose Study (TLGS) cohort. About 50% of the inter-individual variation in serum HDL-C levels is genetical...

    Authors: Mohammad Ali Kashani Farid, Fereidoun Azizi, Mehdi Hedayati, Maryam S Daneshpour, Ahmad Reza Shamshiri and Fereydoun Siassi
    Citation: Lipids in Health and Disease 2010 9:96
    Content type: Research Published on:

  42. Pathological left ventricular (LV) hypertrophy frequently progresses to dilated heart failure with suppressed mitochondrial oxidative capacity. Dietary marine ω-3 polyunsaturated fatty acids (ω-3 PUFA) up-regu...

    Authors: Karen M O'Shea, David J Chess, Ramzi J Khairallah, Peter A Hecker, Biao Lei, Kenneth Walsh, Christine Des Rosiers and William C Stanley
    Citation: Lipids in Health and Disease 2010 9:95
    Content type: Research Published on:

  43. Dietary modification via caloric restriction is associated with multiple effects related to improved metabolic and cardiovascular health. However, a mandated reduction in kilocalories is not well-tolerated by ...

    Authors: Richard J Bloomer, Mohammad M Kabir, Robert E Canale, John F Trepanowski, Kate E Marshall, Tyler M Farney and Kelley G Hammond
    Citation: Lipids in Health and Disease 2010 9:94
    Content type: Research Published on:

  45. The role of inflammation in the pathogenesis and progression of atherosclerosis has been increasingly discussed. Although the seroepidemiological studies have suggested a relationship between Helicobacter pylori ...

    Authors: Halide S Akbas, Sebahat Basyigit, Inci Suleymanlar, Didem Kemaloglu, Serkan Koc, Fatih Davran, Ibrahim Demir and Gultekin Suleymanlar
    Citation: Lipids in Health and Disease 2010 9:92
    Content type: Research Published on:

  46. The search for sickle cell disease (SCD) prognosis biomarkers is a challenge. These markers identification can help to establish further therapy, later severe clinical complications and with patients follow-up...

    Authors: Magda O Seixas, Larissa C Rocha, Mauricio B Carvalho, Joelma F Menezes, Isa M Lyra, Valma ML Nascimento, Ricardo D Couto, Ájax M Atta, Mitermayer G Reis and Marilda S Goncalves
    Citation: Lipids in Health and Disease 2010 9:91
    Content type: Research Published on:

  47. β2-adrenoceptor (β2AR) gene polymorphism glutamine 27 glutamic acid (Gln27Glu) and Arg16Gly were reported to have an association with obesity and obesity related disorders in some population. We evaluated Gln2...

    Authors: Maha H Daghestani, Arjumand Warsy, Mazin H Daghestani, Ali N Al-odaib, Abdelmoneim Eldali, Nadia A Al-Eisa and Sabah Al-zhrani
    Citation: Lipids in Health and Disease 2010 9:90
    Content type: Research Published on:

  48. Oxidative stress produced by reactive oxygen species (ROS) has been linked to the development of several diseases such as cardiovascular, cancer, and neurodegenerative diseases. This study investigates the pos...

    Authors: Amel Nakbi, Wafa Tayeb, Samia Dabbou, Manel Issaoui, Abir K Grissa, Nabil Attia and Mohamed Hammami
    Citation: Lipids in Health and Disease 2010 9:89
    Content type: Research Published on:

  49. The objective of present study was to provide the pharmacological basis for the medicinal use of Morinda citrifolia Linn in dyslipidemia using the aqueous-ethanolic extracts of its fruits (Mc.Cr.F), leaves (Mc.Cr...

    Authors: Saf-ur Rehman Mandukhail, Nauman Aziz and Anwarul-Hassan Gilani
    Citation: Lipids in Health and Disease 2010 9:88
    Content type: Research Published on:

  50. Although advanced age is considered a risk factor for several diseases, the impact of gender on age-associated cardiovascular diseases, such as atherosclerotic processes and valvular diseases, remains not comp...

    Authors: Thiago M. C. Pereira, Breno V. Nogueira, Leandro C. F. Lima, Marcella L. Porto, Jose A. Arruda, Elisardo C. Vasquez and Silvana S. Meyrelles
    Citation: Lipids in Health and Disease 2010 9:87
    Content type: Research Published on:
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Lipids in Health and Disease

ISSN: 1476-511X