Hosokawa M, Kudo M, Maeda H, Kohno H, Tanaka T, Miyashita K: Fucoxanthin induces apoptosis and enhances the antiproliferative effect of the PPARgamma ligand, troglitazone, on colon cancer cells. Biochim Biophys Acta. 2004, 1675: 113-119. 10.1016/j.bbagen.2004.08.012
Article
CAS
PubMed
Google Scholar
Shiratori K, Ohgami K, Ilieva I, Jin XH, Koyama Y, Miyashita K, Yoshida K, Kase S, Ohno S: Effects of fucoxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo. Exp Eye Res. 2005, 81: 422-428. 10.1016/j.exer.2005.03.002
Article
CAS
PubMed
Google Scholar
Sachindra NM, Sato E, Maeda H, Hosokawa M, Niwano Y, Kohno M, Miyashita K: Radical scavenging and singlet oxygen quenching activity of marine carotenoid fucoxanthin and its metabolites. J Agric Food Chem. 2007, 55: 8516-8522. 10.1021/jf071848a
Article
CAS
PubMed
Google Scholar
Hosokawa M, Miyashita T, Nishikawa S, Emi S, Tsukui T, Beppu F, Okada T, Miyashita K: Fucoxanthin regulates adipocytokine mRNA expression in white adipose tissue of diabetic/obese KK-Ay mice. Arch Biochem Biophys. 2010, 504: 17-25. 10.1016/j.abb.2010.05.031
Article
CAS
PubMed
Google Scholar
Kadekaru T, Toyama H, Yasumoto T: Safety evaluation of fucoxanthin purified from undariapinnatifida. Nippon Shokuhin Kagaku Kogaku Kaishi. 2008, 55: 304-308. 10.3136/nskkk.55.304. 10.3136/nskkk.55.304
Article
CAS
Google Scholar
Beppu F, Niwano Y, Tsukui T, Hosokawa M, Miyashita K: Single and repeated oral dose toxicity study of fucoxanthin (FX), a marine carotenoid, in mice. J Toxicol Sci. 2009, 34: 501-510. 10.2131/jts.34.501
Article
CAS
PubMed
Google Scholar
Woo MN, Jeon SM, Kim HJ, Lee MK, Shin SK, Shin YC, Park YB, Choi MS: Fucoxanthin supplementation improves plasma and hepatic lipid metabolism and blood glucose concentration in high-fat fed C57BL/6 N mice. Chem Biol Interact. 2010, 186: 316-322. 10.1016/j.cbi.2010.05.006
Article
CAS
PubMed
Google Scholar
Tsukui T, Konno K, Hosokawa M, Maeda H, Sashima T, Miyashita K: Fucoxanthin and fucoxanthinol enhance the amount of docosahexaenoic acid in the liver of KKAy obese/diabetic mice. J Agric Food Chem. 2007, 55: 5025-5029. 10.1021/jf070110q
Article
CAS
PubMed
Google Scholar
Jeon SM, Kim HJ, Woo MN, Lee MK, Shin YC, Park YB, Choi MS: Fucoxanthin-rich seaweed extract suppresses body weight gain and improves lipid metabolism in high-fat-fed C57BL/6 J mice. Biotechnol J. 2010, 5: 961-969. 10.1002/biot.201000215
Article
CAS
PubMed
Google Scholar
Folch J, Lees M, Sloane Stanley GH: A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem. 1957, 226: 497-509.
CAS
PubMed
Google Scholar
Hua X, Yokoyama C, Wu J, Briggs MR, Brown MS, Goldstein JL, Wang X: SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element. Proc Natl Acad Sci USA. 1993, 90: 11603-11607. 10.1073/pnas.90.24.11603
Article
PubMed Central
CAS
PubMed
Google Scholar
Brown MS, Goldstein JL: The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell. 1997, 89: 331-340. 10.1016/S0092-8674(00)80213-5
Article
CAS
PubMed
Google Scholar
Timmins JM, Lee JY, Mulya A: Tissue-specific hepatic deletion of ABCA1 indicates that the liver is the primary site for HDL formation in vivo [abstract]. Arterioscler Thromb Vasc Biol. 2004, 24: 52-
Google Scholar
Brown MS, Goldstein JL: Lowering LDL – not only how low, but how long?. Science. 2006, 311: 1721-1723. 10.1126/science.1125884
Article
CAS
PubMed
Google Scholar
Attie AD, Seidah NG: Dual regulation of the LDL receptor–some clarity and new questions. Cell Metab. 2005, 1: 290-292. 10.1016/j.cmet.2005.04.006
Article
CAS
PubMed
Google Scholar
Maeda H, Hosokawa M, Sashima T, Funayama K, Miyashita K: Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues. Biochem Biophys Res Commun. 2005, 332: 392-397. 10.1016/j.bbrc.2005.05.002
Article
CAS
PubMed
Google Scholar
Abidov M, Ramazanov Z, Seifulla R, Grachev S: The effects of Xanthigen in the weight management of obese premenopausal women with non-alcoholic fatty liver disease and normal liver fat. Diabetes Obes Metab. 2010, 12: 72-81. 10.1111/j.1463-1326.2009.01132.x
Article
CAS
PubMed
Google Scholar
Rigotti A, Trigatti BL, Penman M, Rayburn H, Herz J, Krieger M: A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism. Proc Natl Acad Sci USA. 1997, 94: 12610-12615. 10.1073/pnas.94.23.12610
Article
PubMed Central
CAS
PubMed
Google Scholar
Varban ML, Rinninger F, Wang N, Fairchild-Huntress V, Dunmore JH, Fang Q, Gosselin ML, Dixon KL, Deeds JD, Acton SL, Tall AR, Huszar D: Targeted mutation reveals a central role for SR-BI in hepatic selective uptake of high density lipoprotein cholesterol. Proc Natl Acad Sci USA. 1998, 95: 4619-4624. 10.1073/pnas.95.8.4619
Article
PubMed Central
CAS
PubMed
Google Scholar
Wang N, Arai T, Ji Y, Rinninger F, Tall AR: Liver-specific overexpression of scavenger receptor BI decreases levels of very low density lipoprotein ApoB, low density lipoprotein ApoB, and high density lipoprotein in transgenic mice. J Biol Chem. 1998, 273: 32920-32926. 10.1074/jbc.273.49.32920
Article
CAS
PubMed
Google Scholar
Brown MS, Goldstein JL: A receptor-mediated pathway for cholesterol homeostasis. Science. 1986, 232: 34-47. 10.1126/science.3513311
Article
CAS
PubMed
Google Scholar
Rigotti A, Miettinen HE, Krieger M: The role of the high-density lipoprotein receptor SR-BI in the lipid metabolism of endocrine and other tissues. Endocr Rev. 2003, 24: 357-387. 10.1210/er.2001-0037
Article
CAS
PubMed
Google Scholar
Soumian S, Albrecht C, Davies AH, Gibbs RG: ABCA1 and atherosclerosis. Vasc Med. 2005, 10: 109-119. 10.1191/1358863x05vm593ra
Article
CAS
PubMed
Google Scholar
Quintão E, Grundy SM, Ahrens EH: Effects of dietary cholesterol on the regulation of total body cholesterol in man. J Lipid Res. 1971, 12: 233-247.
PubMed
Google Scholar
Farkas J, Angel A, Avigan MI: Studies on the compartmentation of lipid in adipose cells. II. Cholesterol accumulation and distribution in adipose tissue components. J Lipid Res. 1973, 14: 344-356.
CAS
PubMed
Google Scholar
Benjannet S, Rhainds D, Essalmani R, Mayne J, Wickham L, Jin W, Asselin MC, Hamelin J, Varret M, Allard D, Trillard M, Abifadel M, Tebon A, Attie AD, Rader DJ, Boileau C, Brissette L, Chrétien M, Prat A, Seidah NG: NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol. J Biol Chem. 2004, 279: 48865-48875. 10.1074/jbc.M409699200
Article
CAS
PubMed
Google Scholar
Park SW, Moon YA, Horton JD: Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver. J Biol Chem. 2004, 279: 50630-50638. 10.1074/jbc.M410077200
Article
CAS
PubMed
Google Scholar
Zelcer N, Hong C, Boyadjian R, Tontonoz P: LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor. Science. 2009, 325: 100-104. 10.1126/science.1168974
Article
PubMed Central
CAS
PubMed
Google Scholar
Seidah NG, Benjannet S, Wickham L, Marcinkiewicz J, Jasmin SB, Stifani S, Basak A, Prat A, Chretien M: The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation. Proc Natl Acad Sci USA. 2003, 100: 928-933. 10.1073/pnas.0335507100
Article
PubMed Central
CAS
PubMed
Google Scholar
Zhang DW, Lagace TA, Garuti R, Zhao Z, McDonald M, Horton JD, Cohen JC, Hobbs HH: Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation. J Biol Chem. 2007, 282: 18602-18612. 10.1074/jbc.M702027200
Article
CAS
PubMed
Google Scholar
Park SW, Moon YA, Horton JD: Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver. J Biol Chem. 2004, 279: 50630-50638. 10.1074/jbc.M410077200
Article
CAS
PubMed
Google Scholar
Horton JD, Shah NA, Warrington JA, Anderson NN, Park SW, Brown MS, Goldstein JL: Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes. Proc Natl Acad Sci USA. 2003, 100: 12027-12032. 10.1073/pnas.1534923100
Article
PubMed Central
CAS
PubMed
Google Scholar
Maxwell KN, Soccio RE, Duncan EM, Sehayek E, Breslow JL: Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice. J Lipid Res. 2003, 44: 2109-2119. 10.1194/jlr.M300203-JLR200
Article
CAS
PubMed
Google Scholar
Trigatti B, Rigotti A, Krieger M: The role of the high-density lipoprotein receptor SR-BI in cholesterol metabolism. Curr Opin Lipidol. 2000, 11: 123-131. 10.1097/00041433-200004000-00004
Article
CAS
PubMed
Google Scholar
Malerød L, Juvet LK, Hanssen-Bauer A, Eskild W, Berg T: Oxysterol-activated LXRalpha/RXR induces hSR-BI-promoter activity in hepatoma cells and preadipocytes. Biochem Biophys Res Commun. 2002, 299: 916-923. 10.1016/S0006-291X(02)02760-2
Article
PubMed
Google Scholar
Mardones P, Pilon A, Bouly M, Duran D, Nishimoto T, Arai H, Kozarsky KF, Altayo M, Miquel JF, Luc G, Clavey V, Staels B, Rigotti A: Fibrates down-regulate hepatic scavenger receptor class B type I protein expression in mice. J Biol Chem. 2003, 278: 7884-7890. 10.1074/jbc.M211627200
Article
CAS
PubMed
Google Scholar