Articles

Performance of liver stiffness measurements obtained with FibroScan is affected by glucose metabolism in patients with nonalcoholic fatty liver disease

The performance of liver stiffness measurements (LSMs) obtained using FibroScan can be affected by several factors, and cut-off values are different for fibrosis caused by various aetiologies. The study aims t...

Authors: Xinyu Yang, Xinxia Chang, Shengdi Wu, Xiaoyang Sun, Xiaopeng Zhu, Liu Wang, Yushan Xu, Xiuzhong Yao, Shengxiang Rao, Xiqi Hu, Mingfeng Xia, Hua Bian, Hongmei Yan and Xin Gao

Risk factors for cholesterol polyp formation in the gallbladder are closely related to lipid metabolism

The purpose of this study was to assess the risk factors for cholesterol polyp formation in the gallbladder.

Authors: Zhihao Yu, Changlin Yang, Xuesong Bai, Guibin Yao, Xia Qian, Wei Gao, Yue Huang, Xiaodong Tian, Shi Cheng and Yamin Zheng

Correlation analysis of epicardial adipose tissue thickness, C-reactive protein, interleukin-6, visfatin, juxtaposed with another zinc finger protein 1, and type 2 diabetic macroangiopathy

To investigate the correlation between the thickness of epicardial adipose tissue (EAT), C-reactive protein (CRP), interleukin (IL) -6, visfatin, juxtaposed with another zinc finger protein 1 (JAZF1) and type ...

Authors: Yuan-Yuan Gong and Hai-Ying Peng

Structure-dependent absorption of atypical sphingoid long-chain bases from digestive tract into lymph

Dietary sphingolipids have various biofunctions, including skin barrier improvement and anti-inflammatory and anti-carcinoma properties. Long-chain bases (LCBs), the essential backbones of sphingolipids, are e...

Authors: Daisuke Mikami, Shota Sakai, Megumi Nishimukai, Kohei Yuyama, Katsuyuki Mukai and Yasuyuki Igarashi

The impact of reactive oxygen species in the development of cardiometabolic disorders: a review

Oxidative stress, an alteration in the balance between reactive oxygen species (ROS) generation and antioxidant buffering capacity, has been implicated in the pathogenesis of cardiometabolic disorders (CMD). A...

Authors: Roland Akhigbe and Ayodeji Ajayi

Compositional alterations of gut microbiota in nonalcoholic fatty liver disease patients: a systematic review and Meta-analysis

Although imbalanced intestinal flora contributes to the pathogenesis of nonalcoholic fatty liver disease (NAFLD), conflicting results have been obtained for patient-derived microbiome composition analyses. A m...

Authors: Fuxi Li, Junzhao Ye, Congxiang Shao and Bihui Zhong

The effect of temperature on the stability of PCSK-9 monoclonal antibody: an experimental study

PCSK9 monoclonal antibody lowers plasma PCSK9 and LDL-cholesterol levels. The manufacturers recommend drug storage at 2–8 °C, and not above 25 °C. This study aimed to investigate drug stability at various temp...

Authors: Tanawan Kongmalai, Nalinee Chuanchaiyakul, Chattip Sripatumtong, Tunsuda Tansit, Yuttana Srinoulprasert, Nareerak Klinsukon and Nuntakorn Thongtang

A cohort study on risk factors of high-density lipoprotein cholesterol hypolipidemia among urban Chinese adults

High-density lipoprotein cholesterol (HDL-C) hypolipidemia, a major type of dyslipidemia, has been associated with many kinds of diseases, such as stroke, coronary heart disease, obesity and diabetes, and has ...

Authors: Fang Tang, Jian Wang, Stephen Nicholas, Dongfu Qian and Rugang Liu

Role of ASM/Cer/TXNIP signaling module in the NLRP3 inflammasome activation

This study aimed to explore the effects of ceramide (Cer) on NLRP3 inflammasome activation and their underlying mechanisms.

Authors: Jianjun Jiang, Yining Shi, Jiyu Cao, Youjin Lu, Gengyun Sun and Jin Yang

A meta-analysis of HDL cholesterol efflux capacity and concentration in patients with rheumatoid arthritis

Poor cholesterol efflux capacity (CEC) has been proposed to be an independent risk factor for cardiovascular diseases. However, current evidence is inconsistent, especially in rheumatoid arthritis (RA) patient...

Authors: Binbin Xie, Jiang He, Yong Liu, Ting Liu and Chaoqun Liu

Pemafibrate decreases triglycerides and small, dense LDL, but increases LDL-C depending on baseline triglycerides and LDL-C in type 2 diabetes patients with hypertriglyceridemia: an observational study

Pemafibrate, a selective PPARα modulator, has the beneficial effects on serum triglycerides (TGs) and very low density lipoprotein (VLDL), especially in patients with diabetes mellitus or metabolic syndrome. H...

Authors: Ichiro Komiya, Akira Yamamoto, Suguru Sunakawa and Tamio Wakugami

Metabolic profiling reveals interleukin-17A monoclonal antibody treatment ameliorate lipids metabolism with the potentiality to reduce cardiovascular risk in psoriasis patients

Psoriasis is a common chronic inflammatory skin disease associated with overproduction of interleukin-17A (IL-17A). IL-17A monoclonal antibodies (mAbs) have shown clinical efficacy in psoriasis patients. Altho...

Authors: Han Cao, Shengmin Su, Qi Yang, Yunchen Le, Lihong Chen, Mengyan Hu, Xiaoyu Guo, Jie Zheng, Xia Li and Yunqiu Yu

Identification of lipidomic profiles associated with drug-resistant prostate cancer cells

The association of circulating lipids with clinical outcomes of drug-resistant castration-resistant prostate cancer (DR-CRPC) is not fully understood. While it is known that increases in select lipids correlat...

Authors: Lishann M. Ingram, Morgan C. Finnerty, Maryam Mansoura, Chau-Wen Chou and Brian S. Cummings

Familial hypertriglyceridemia: an entity with distinguishable features from other causes of hypertriglyceridemia

Familial hypertriglyceridemia (FHTG) is a partially characterized primary dyslipidemia which is frequently confused with other forms hypertriglyceridemia. The aim of this work is to search for specific feature...

Authors: Ivette Cruz-Bautista, Alicia Huerta-Chagoya, Hortensia Moreno-Macías, Rosario Rodríguez-Guillén, María Luisa Ordóñez-Sánchez, Yayoi Segura-Kato, Roopa Mehta, Paloma Almeda-Valdés, Lizeth Gómez-Munguía, Ximena Ruiz-De Chávez, Ximena Rosas-Flota, Arali Andrade-Amado, Bárbara Bernal-Barroeta, María Guadalupe López-Carrasco, Luz Elizabeth Guillén-Pineda, Angelina López-Estrada…

Triglycerides to high-density lipoprotein cholesterol ratio is superior to triglycerides and other lipid ratios as an indicator of increased urinary albumin-to-creatinine ratio in the general population of China: a cross-sectional study

Dyslipidemia contributes to the pathogenesis of renal dysfunction. Previous research demonstrated that triglycerides (TG), instead of other individual lipid indexes, has a significant link with elevated urinar...

Authors: Jing Xue, Yuxia Wang, Bing Li, Songyan Yu, Anping Wang, Weiqing Wang, Zhengnan Gao, Xulei Tang, Li Yan, Qin Wan, Guijun Qin, Lulu Chen, Guang Ning and Yiming Mu

Lipoprotein-associated phospholipase A2 levels, endothelial dysfunction and arterial stiffness in patients with stable coronary artery disease

Lipoprotein-associated Phospholipase A2 (Lp-PLA2), can exert proinflammatory as well as proatherogenic properties on the vascular wall. The current study sought to evaluate the influence of high Lp-PLA2 levels...

Authors: Konstantinos Mourouzis, Gerasimos Siasos, Evangelos Oikonomou, Marina Zaromitidou, Vicky Tsigkou, Alexis Antonopoulos, Evanthia Bletsa, Panagiota Stampouloglou, Konstantinos Vlasis, Manolis Vavuranakis and Dimitris Tousoulis

Genetic factors increase the identification efficiency of predictive models for dyslipidaemia: a prospective cohort study

Few studies have developed risk models for dyslipidaemia, especially for rural populations. Furthermore, the performance of genetic factors in predicting dyslipidaemia has not been explored. The purpose of thi...

Authors: Miaomiao Niu, Liying Zhang, Yikang Wang, Runqi Tu, Xiaotian Liu, Jian Hou, Wenqian Huo, Zhenxing Mao, Zhenfei Wang and Chongjian Wang

Discordant serum lipid parameters

Authors: Ozge Kurmus, Turgay Aslan, Murat Eren, Kursat Akbuga, Liliana Fonseca, Silvia Paredes and Isabel Palma

The association of parameters of body composition and laboratory markers with the severity of hypertriglyceridemia-induced pancreatitis

Hypertriglyceridemia has arisen as the third leading cause of acute pancreatitis. This study aimed at exploring the association between the severity of hypertriglyceridemia-induced pancreatitis (HTGP) and comp...

Authors: Lifang Chen, Yingbao Huang, Huajun Yu, Kehua Pan, Zhao Zhang, Yi Man and Dingyuan Hu

Correction to: Association between triglyceride-glucose index and risk of incident diabetes: a secondary analysis based on a Chinese cohort study

An amendment to this paper has been published and can be accessed via the original article.

Authors: Xiaoli Li, Guilong Li, Tiantian Cheng, Jing Liu, Guangyao Song and Huijuan Ma

The effects of canola and olive oils consumption compared to sunflower oil, on lipid profile and hepatic steatosis in women with polycystic ovarian syndrome: a randomized controlled trial

Polycystic Ovarian Syndrome (PCOS) is one of the most common endocrinopathies and metabolic disorders in women during their reproductive years. It is often associated with dyslipidemia and other risk factors o...

Authors: Maryam Yahay, Zahra Heidari, Zahra Allameh and Reza Amani

Proprotein convertase subtilisin/kexin type 9 (PCSK9) levels are not associated with severity of liver disease and are inversely related to cholesterol in a cohort of thirty eight patients with liver cirrhosis

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is of particular importance in cholesterol metabolism with high levels contributing to hypercholesterolemia. Cholesterol and sphingolipids are low in patie...

Authors: Susanne Feder, Reiner Wiest, Thomas S. Weiss, Charalampos Aslanidis, Doris Schacherer, Sabrina Krautbauer, Gerhard Liebisch and Christa Buechler

Empagliflozin protects against atherosclerosis progression by modulating lipid profiles and sympathetic activity

Several large clinical trials have confirmed the cardioprotective role of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in patients with type 2 diabetes. However, whether empagliflozin, as an SGLT2i, coul...

Authors: Yihai Liu, Jiamin Xu, Mingyue Wu, Biao Xu and Lina Kang

Evaluation of cardiovascular risk factors in patients with familial hypercholesterolemia from the North-Eastern area of Romania

Familial hypercholesterolemia(FH) is one of the most frequent and important monogenic cholesterol pathologies. Traditional and non-traditional cardiovascular risk factors increase the prevalence of atheroscler...

Authors: Cristiana-Elena Vlad, Liliana Foia, Laura Florea, Irina-Iuliana Costache, Andreea Covic, Roxana Popescu, Delia Reurean-Pintilei and Adrian Covic

Association between lipoprotein cholesterol and future cardiovascular disease and mortality in older adults: a Korean nationwide longitudinal study

Dyslipidemia is considered an independent health risk factor of cardiovascular disease (CVD), a leading cause of mortality in older adults. Despite its importance, there have been few reports on the associatio...

Authors: Seung Hee Kim and Ki Young Son

LDL-cholesterol change and goal attainment following statin intensity titration among Asians in primary care: a retrospective cohort study

Clinical trials have demonstrated that either initiating or up-titrating a statin dose substantially reduce Low-Density Lipoprotein-Cholesterol (LDL-C) levels. However, statin adherence in actual practice tend...

Authors: Hao Sen Andrew Fang, Qiao Gao, Mong Li Lee, Wynne Hsu and Ngiap Chuan Tan

Association between serum uric acid and triglycerides in Chinese children and adolescents with short stature

Elevated triglyceride (TG) levels are a biomarker for cardiovascular disease (CVD) risk. The correlation between serum uric acid (SUA) and TG concentrations in adults or obese children is well established. How...

Authors: Yuntian Chu, Qianqian Zhao, Mei Zhang, Bo Ban and Hongbing Tao

A trans fatty acid substitute enhanced development of liver proliferative lesions induced in mice by feeding a choline-deficient, methionine-lowered, L-amino acid-defined, high-fat diet

Nonalcoholic steatohepatitis (NASH) is a form of liver disease characterized by steatosis, necroinflammation, and fibrosis, resulting in cirrhosis and cancer. Efforts have focused on reducing the intake of trans ...

Authors: Noriko Suzuki-Kemuriyama, Akari Abe, Kiniko Uno, Shuji Ogawa, Atsushi Watanabe, Ryuhei Sano, Megumi Yuki, Katsuhiro Miyajima and Dai Nakae

Hepatic lipid profile in mice fed a choline-deficient, low-methionine diet resembles human non-alcoholic fatty liver disease

Emerging data support a role for lipids in non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC) in humans. With experimental models such data can be challenged or validated. Mice fed a low-m...

Authors: Elisabeth M. Haberl, Rebekka Pohl, Lisa Rein-Fischboeck, Marcus Höring, Sabrina Krautbauer, Gerhard Liebisch and Christa Buechler

The associations between p,p’-DDE levels and plasma levels of lipoproteins and their subclasses in an elderly population determined by analysis of lipoprotein content

Lipoproteins at aberrant levels are known to play a role in cardiovascular disease. The metabolite of the insecticide dichlorodiphenyltrichloroethane (DDT), p,p’-dichlorodiphenyldichloroethylene (p,p’-DDE), ph...

Authors: Juliann Jugan, P. Monica Lind, Samira Salihovic, Jordan Stubleski, Anna Kärrman, Lars Lind and Michele A. La Merrill

Relationship between serum triglyceride to high-density lipoprotein cholesterol ratio and sarcopenia occurrence rate in community-dwelling Chinese adults

A study conducted on elderly Korean men showed that a high serum triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio was associated with a high risk of developing sarcopenia. We aimed to dete...

Authors: Na Wang, Mengjun Chen and Danhong Fang

The extended lipid panel assay: a clinically-deployed high-throughput nuclear magnetic resonance method for the simultaneous measurement of lipids and Apolipoprotein B

Standard lipid panel assays employing chemical/enzymatic methods measure total cholesterol (TC), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C), from which are calculated estimates of low...

Authors: Erwin Garcia, Dennis W. Bennett, Margery A. Connelly, Elias J. Jeyarajah, Franklin C. Warf, Irina Shalaurova, Steven P. Matyus, Justyna Wolak-Dinsmore, David N. Oskardmay, Randolph M. Young, Maureen Sampson, Alan T. Remaley and James D. Otvos

Retraction Note: Glycol chitosan incorporated retinoic acid chlorochalcone (RACC) nanoparticles in the treatment of Osteosarcoma

This article has been retracted. Please see the Retraction Notice for more detail: https://​doi.​org/​10.​1186/​s12944-020-01416-2

Authors: Yan-Guo Qin, Lan-Yu Zhu, Chen-Yu Wang, Bo-Yan Zhang, Qing-Yu Wang, Rui-Yan Li and Zhen Liu

Association between the alanine aminotransferase/aspartate aminotransferase ratio and new-onset non-alcoholic fatty liver disease in a nonobese Chinese population: a population-based longitudinal study

The alanine aminotransferase (ALT)/aspartate aminotransferase (AST) ratio has been considered an alternative marker for hepatic steatosis. However, few studies have investigated the association of the ALT/AST ...

Authors: Yang Zou, Ling Zhong, Chong Hu and Guotai Sheng

Association of dietary pattern and physical activity with lipid-related indices among Chinese population: a cross-sectional study

To explore the relationship between dietary patterns, physical activity and lipid-related indices in Chinese Population.

Authors: Qiao Guo, Zuchang Ma, Changan Zhu and Qiang Zeng

Inverse association between triglyceride glucose index and muscle mass in Korean adults: 2008–2011 KNHANES

Since sarcopenia is an important risk factor for falls or cardiovascular disease, early detection and prevention of sarcopenia are being increasingly emphasized. Emerging evidence has indicated relationships b...

Authors: Sung-Ho Ahn, Jun-Hyuk Lee and Ji-Won Lee

Association between the non-HDL-cholesterol to HDL-cholesterol ratio and non-alcoholic fatty liver disease in Chinese children and adolescents: a large single-center cross-sectional study

The non-HDL-cholesterol to HDL-cholesterol (NHDLC/HDLC) ratio is closely related to a variety of dyslipidemia-related diseases. This study examined the relationship between the NHDLC/HDLC ratio and non-alcohol...

Authors: Shouxing Yang, Jinwei Zhong, Mengsi Ye, Lei Miao, Guangrong Lu, Changlong Xu, Zhanxiong Xue and Xinhe Zhou

Emerging insights into the relationship between hyperlipidemia and the risk of diabetic retinopathy

Hyperlipidemia is correlated with a series of health problems. Notably, aside from its established role in promoting cardiovascular morbidity and mortality, hyperlipidemia has also been considered for modulati...

Authors: Yuyu Chou, Jin Ma, Xin Su and Yong Zhong

Prognostic impact of the atherogenic index of plasma in type 2 diabetes mellitus patients with acute coronary syndrome undergoing percutaneous coronary intervention

The association of the atherogenic index of plasma (AIP), an emerging lipid index that can predict the risk for cardiovascular disease, with adverse outcomes in type 2 diabetes mellitus (T2DM) patients with ac...

Authors: Xiaoteng Ma, Yan Sun, Yujing Cheng, Hua Shen, Fei Gao, Jing Qi, Lixia Yang, Zhijian Wang, Dongmei Shi, Yuyang Liu, Xiaoli Liu and Yujie Zhou

Pharmacokinetics and pharmacodynamics of HTD1801 (berberine ursodeoxycholate, BUDCA) in patients with hyperlipidemia

Reduction in elevated serum cholesterol concentrations is important in the management of individuals at risk of atherosclerotic cardiovascular disease (ASCVD), such as myocardial infarction and thrombotic stro...

Authors: Adrian M. Di Bisceglie, Gerald F. Watts, Philip Lavin, Meng Yu, Ru Bai and Liping Liu

A U-shaped association between the LDL-cholesterol to HDL-cholesterol ratio and all-cause mortality in elderly hypertensive patients: a prospective cohort study

The low-density lipoprotein cholesterol/high-density lipoprotein- cholesterol (LDL-C/HDL-C) ratio is an excellent predictor of cardiovascular disease (CVD). However, previous studies linking the LDL-C/HDL-C ra...

Authors: Yu Yu, Minghui Li, Xiao Huang, Wei Zhou, Tao Wang, Lingjuan Zhu, Congcong Ding, Yu Tao, Huihui Bao and Xiaoshu Cheng

Utilization of statins and LDL-cholesterol target attainment in Turkish patients with type 2 diabetes - a nationwide cross-sectional study (TEMD dyslipidemia study)

Attaining acceptable levels of LDL Cholesterol (LDL-C) significantly improves cardiovascular (CV) outcomes in patients with type 2 diabetes mellitus (T2DM). The LDL-C target attainment and the characteristics ...

Authors: Fahri Bayram, Alper Sonmez, Cem Haymana, Tevfik Sabuncu, Oguzhan Sitki Dizdar, Eren Gurkan, Ayse Kargili Carlioglu, Kemal Agbaht, Didem Ozdemir, Ibrahim Demirci, Cem Barcin, Serpil Salman, Tamer Tetiker, Mustafa Kemal Balci, Nur Kebapci, Canan Ersoy…

Association between triglyceride-glucose index and risk of incident diabetes: a secondary analysis based on a Chinese cohort study

Recent studies have suggested the triglyceride-glucose index (TyG index) may serve as a suitable substitute for insulin resistance. However, evidence for the relationship between TyG index and risk of diabetes...

Authors: Xiaoli Li, Guilong Li, Tiantian Cheng, Jing Liu, Guangyao Song and Huijuan Ma

Evaluation of lipid ratios and triglyceride-glucose index as risk markers of insulin resistance in Iranian polycystic ovary syndrome women

Insulin resistance has a vital role in the pathophysiology of polycystic ovary syndrome (PCOS). Previous investigations have shown that some lipid ratios could be a simple clinical indicator of insulin resista...

Authors: Asma Kheirollahi, Maryam Teimouri, Mehrdad Karimi, Akram Vatannejad, Nariman Moradi, Nasrin Borumandnia and Asie Sadeghi

Hyperlipidemia and mortality associated with diabetes mellitus co-existence in Chinese peritoneal dialysis patients

To evaluate associations between diabetes mellitus (DM) coexisting with hyperlipidemia and mortality in peritoneal dialysis (PD) patients.

Authors: Xin Wei, Yueqiang Wen, Qian Zhou, Xiaoran Feng, Fen Fen Peng, Niansong Wang, Xiaoyang Wang and Xianfeng Wu

Bidirectional association between serum carcinoembryonic antigen and metabolic syndrome among the Chinese male population: two cohort studies

Previous studies have shown that serum carcinoembryonic antigen (CEA) is independently associated with metabolic syndrome (MetS). However, these studies were mainly cross-sectional analyses, and cause was not ...

Authors: Yafei Liu, Zhaohui Du, Jiadong Ji, Jingru Li, Deming Bi and Fang Tang

Association between statin use and osteoporotic fracture in patients with chronic obstructive pulmonary disease: a population-based, matched case-control study

In the recent years, chronic obstructive pulmonary disease (COPD) has been found to be associated with a higher risk of new-onset osteoporotic fracture (NOF). However, the existence of such an association in t...

Authors: Hung-Yi Chen, Pei-Yu Su, Tsung-Kun Lin and Gwo-Ping Jong

Association between nontraditional lipid profiles and peripheral arterial disease in Chinese adults with hypertension

Data on the relationship between nontraditional lipid profiles [total cholesterol (TC)/high-density lipoprotein cholesterol (HDL-C) ratio, triglyceride (TG)/HDL-C ratio, low-density lipoprotein cholesterol (LD...

Authors: Congcong Ding, Yang Chen, Yumeng Shi, Minghui Li, Lihua Hu, Wei Zhou, Tao Wang, Lingjuan Zhu, Xiao Huang, Huihui Bao and Xiaoshu Cheng

Characterization of the serum levels of Meteorin-like in patients with inflammatory bowel disease and its association with inflammatory cytokines

Meteorin-like (Metrnl) is an adipokine with insulin sensitizing and anti-inflammatory properties that has been discovered recently. The relation among Metrnl, Inflammatory Bowel Disease (IBD), and obesity has ...

Authors: Afsane Gholamrezayi, Maryam Mohamadinarab, Pegah Rahbarinejad, Soudabeh Fallah, Shekufe Rezghi Barez, Leila Setayesh, Nariman Moradi, Reza Fadaei, Elham Chamani and Tahmine Tavakoli

Association between triglyceride glucose-body mass index and non-alcoholic fatty liver disease in the non-obese Chinese population with normal blood lipid levels: a secondary analysis based on a prospective cohort study

Both triglyceride glucose-body mass index (TyG-BMI) and non-alcoholic fatty liver disease (NAFLD) are linked to insulin resistance (IR). Prospective studies linking TyG-BMI to NAFLD have been limited by short ...

Authors: Yaling Li, Rui Zheng, Jie Li, Shuyi Feng, Li Wang and Zhiming Huang