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  1. Content type: Review

    Studies had investigated the associations between proprotein convertase subtilisin/kexin type 9 SNP rs562556 and serum lipids levels and response to statin treatment, however, the results remained inconclusive...

    Authors: Junlan Chuan, Zhengxu Qian, Yuan Zhang, Rongsheng Tong and Min Peng

    Citation: Lipids in Health and Disease 2019 18:105

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  2. Content type: Research

    In recent years, an increasing number of studies have proved that circulating miRNAs could be used for the early diagnosis of cardiovascular diseases and even play vital roles in the evaluation of therapeutic ...

    Authors: Jiang Xu, Zixuan Chen, Yingge Wang, Xiaohong Wang, Lu Chen, Tingting Yuan, Xiangming Tang, Yaoyao Lu, Hongmei Chen, Miaolei Chen, Zuowei Duan, Jianglin Fan, Jingyan Liang and Xinjiang Zhang

    Citation: Lipids in Health and Disease 2019 18:104

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  3. Content type: Research

    Patients with diabetes mellitus were often accompanied with hyperlipidemia. ATP-binding cassette sub-family A member1 (ABCA1) promotes the efflux of lipids and thereby mediates the metabolism of cholesterol. T...

    Authors: Huili Yan, Lei Cheng, Ruoshuang Jia, Huiqian Yao, Hongxia Wu, Yaqian Shen, Ying Zhang, Panpan Hao and Zhongwen Zhang

    Citation: Lipids in Health and Disease 2019 18:103

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  4. Content type: Research

    We previously reported that the consumption of 8 g of protein per day in the form of lactic-fermented egg white (LAFEW) improves visceral fat obesity. In this study, we investigated the minimum effective intak...

    Authors: Ryosuke Matsuoka, Keiko Kamachi, Mika Usuda, Yasunobu Masuda, Masaaki Kunou, Akira Tanaka and Kazunori Utsunomiya

    Citation: Lipids in Health and Disease 2019 18:102

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  5. Content type: Review

    Growing evidence suggests that ethanolamine plasmalogens (PlsEtns), a subtype of phospholipids, have a close association with Alzheimer’s disease (AD). Decreased levels of PlsEtns have been commonly found in A...

    Authors: Xiao Q. Su, Junming Wang and Andrew J. Sinclair

    Citation: Lipids in Health and Disease 2019 18:100

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  6. Content type: Research

    The value of atherogenic index of plasma (AIP) as a predictive biomarker for coronary artery disease (CAD) remains controversial. In addition, whether AIP is associated with the risk of acute coronary syndrome...

    Authors: Gaojun Cai, Wei Liu, Sai Lv, Xu Wang, Yonghe Guo, Zhenxian Yan, Yu Du and Yujie Zhou

    Citation: Lipids in Health and Disease 2019 18:99

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  7. Content type: Research

    Essential hypertension can cause many kinds of cardiovascular diseases. The pathogenesis of essential hypertension is very complex, and the mechanism is still unclear. The microRNAs have been identified as nov...

    Authors: Yuanzheng Ye, Jianzhong Yang, Wenkui Lv, Yanmei Lu, Ling Zhang, Ying Zhang, Zulifeiya Musha, Ping Fan, Bin Yang, Xianhui Zhou and Baopeng Tang

    Citation: Lipids in Health and Disease 2019 18:98

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  8. Content type: Research

    Evidence shows that low serum vitamin D concentrations account for an increased risk of obesity by inducing vitamin D receptor (VDR) hypofunction. Although the correlation between single nucleotide polymorphisms ...

    Authors: Fang Shen, Yan Wang, Hualei Sun, Dongdong Zhang, Fei Yu, Songcheng Yu, Han Han, Jun Wang, Yue Ba, Chongjian Wang, Wenjie Li and Xing Li

    Citation: Lipids in Health and Disease 2019 18:97

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  9. Content type: Research

    The majority of pregnant women present an increase in lipids. To investigate the influence of the non-fasting state in the lipid and lipoprotein profile in pregnancy, we have aimed to assess the dynamic change...

    Authors: Yulong Li, Jianxun He, Xiaoli Zeng, Song Zhao, Xuebing Wang and Hui Yuan

    Citation: Lipids in Health and Disease 2019 18:96

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  10. Content type: Research

    The incidence of premature myocardial infarction (PMI) has gradually increased in recent years. Genetics plays a central role in the development of PMI. Familial hypercholesterolemia (FH) is one of the most co...

    Authors: Chongyou Lee, Yuxia Cui, Junxian Song, Sufang Li, Feng Zhang, Manyan Wu, Long Li, Dan Hu and Hong Chen

    Citation: Lipids in Health and Disease 2019 18:95

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  11. Content type: Research

    Obesity, widely recognized as a serious health concern, is characterized by profoundly altered metabolism. However, the intermediate metabolites involved in this change remain largely unknown.

    Authors: Minoo Bagheri, Abolghasem Djazayery, Farshad Farzadfar, Lu Qi, Mir Saeed Yekaninejad, Stella Aslibekyan, Maryam Chamari, Hossein Hassani, Berthold Koletzko and Olaf Uhl

    Citation: Lipids in Health and Disease 2019 18:94

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  12. Content type: Research

    The aim of this study was to evaluate the effect of a simple visceral obesity phenotype, known as the hypertriglyceridemic waist phenotype and its quantitative indicator waist circumference index on the severi...

    Authors: Yanbing Ding, Min Zhang, Lisheng Wang, Tao Yin, Ningzhi Wang, Jian Wu, Jiehua Zhi, Weiwei Chen, Keyan Wu, Weijuan Gong, Weiming Xiao, Zhenglei Xu and Guotao Lu

    Citation: Lipids in Health and Disease 2019 18:93

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  13. Content type: Review

    Several epidemiological studies have investigated the association between dietary fat intake and cardiovascular disease. However, dietary recommendations based on systematic review and meta-analysis might be m...

    Authors: Yongjian Zhu, Yacong Bo and Yanhua Liu

    Citation: Lipids in Health and Disease 2019 18:91

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  14. Content type: Research

    Dyslipidemia is an important modifiable risk factor for cardiovascular disease. It is diagnosed by the presence of an abnormal lipid profile, primarily with elevated levels of plasma cholesterol, triglyceride,...

    Authors: Ploypun Narindrarangkura, William Bosl, Ram Rangsin and Panadda Hatthachote

    Citation: Lipids in Health and Disease 2019 18:90

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  15. Content type: Research

    Elevation of exogenous free fatty acid (FFA) level leads to insulin resistance (IR) in liver, IR is manifested by elevated hepatic glucose production. We aim to study whether inhibition of endogenous fatty aci...

    Authors: Xiu-Ping Bai, Feng Dong, Guo-Hua Yang and Lei Zhang

    Citation: Lipids in Health and Disease 2019 18:89

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  16. Content type: Review

    The aim of this meta-analysis of randomized placebo-controlled trials was to examine whether ursodeoxycholic acid treatment is an effective lipid-lowering agent.

    Authors: Luis E. Simental-Mendía, Mario Simental-Mendía, Adriana Sánchez-García, Maciej Banach, Maria-Corina Serban, Arrigo F. G. Cicero and Amirhossein Sahebkar

    Citation: Lipids in Health and Disease 2019 18:88

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  17. Content type: Research

    The homeostasis of lipid droplets (LDs) plays a crucial role in maintaining the physical metabolic processes in cells, and is regulated by many LD-associated proteins, including perilipin 5 (Plin5) in liver. A...

    Authors: Jin Zhang, Xing Gao, Yuan Yuan, Chao Sun, Yuanlin Zhao, Liming Xiao, Ying Yang, Yu Gu, Risheng Yang, Peizhen Hu, Lijun Zhang, Chao Wang and Jing Ye

    Citation: Lipids in Health and Disease 2019 18:87

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  18. Content type: Research

    Cis- and trans-palmitoleic acids (Cis-POA and trans-POA) are isomers of palmitoleic acid, a monounsaturated fatty acid which affects glucose and lipid metabolism, and reduces insulin resistance. Trans-POA is u...

    Authors: Wen-wen Huang, Bi-hong Hong, Ji-peng Sun, Ran Tan, Kai-kai Bai, Ting Yang, Hao Wu and Rui-zao Yi

    Citation: Lipids in Health and Disease 2019 18:86

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  19. Content type: Research

    Lysophosphatidic acid (LPA) and lysophosphatidylcholine (LPC) are bioactive lysophospholipids involved in the pathogenesis of renal diseases, especially the renal fibrosis. Plasma LPC concentrations in chronic...

    Authors: Anna Michalczyk, Barbara Dołęgowska, Rafał Heryć, Dariusz Chlubek and Krzysztof Safranow

    Citation: Lipids in Health and Disease 2019 18:85

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  20. Content type: Research

    Two important regulators for circulating lipid metabolisms are lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL). In relation to this, glycosylphosphatidylinositol anchored high-density lipoprote...

    Authors: Ryutaro Matsumoto, Katsuhiko Tsunekawa, Yoshifumi Shoho, Yoshimaro Yanagawa, Nobuo Kotajima, Shingo Matsumoto, Osamu Araki, Takao Kimura, Katsuyuki Nakajima and Masami Murakami

    Citation: Lipids in Health and Disease 2019 18:84

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  21. Content type: Research

    Almonds have been shown to lower LDL cholesterol but there is limited information regarding their effects on the dyslipidemia characterized by increased levels of very low density lipoproteins (VLDL) and small...

    Authors: Paul T. Williams, Nathalie Bergeron, Sally Chiu and Ronald M. Krauss

    Citation: Lipids in Health and Disease 2019 18:83

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  22. Content type: Research

    Evidence regarding the correlation between lipoproteins and telomere length in US adults is limited. We aimed to investigate whether lipoproteins was associated with telomere length using US National Health an...

    Authors: Yun-Fen Chen, Kai-Wen Zhou, Gui-zhen Yang and Chi Chen

    Citation: Lipids in Health and Disease 2019 18:80

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  23. Content type: Research

    Lipid profiles disorders frequently occur in patients with chronic liver diseases, and the mortality of cirrhosis complicated with portal vein thrombosis (PVT) remains high. Research identifying simple and obj...

    Authors: Bo Gao, Jiangqiang Xiao, Ming Zhang, Feng Zhang, Wei Zhang, Jian Yang, Jian He, Yu Liu, Xiaoping Zou, Ping Xu and Yuzheng Zhuge

    Citation: Lipids in Health and Disease 2019 18:79

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  24. Content type: Research

    High fat or fructose induces non-alcoholic fatty liver disease (NAFLD) accompanied of mitochondrial dysfunction and oxidative stress. Controversy remains about whether fructose or fat is more deleterious for N...

    Authors: Claudia Isabel García-Berumen, Omar Ortiz-Avila, Manuel Alejandro Vargas-Vargas, Bricia A. del Rosario-Tamayo, Clotilde Guajardo-López, Alfredo Saavedra-Molina, Alain Raimundo Rodríguez-Orozco and Christian Cortés-Rojo

    Citation: Lipids in Health and Disease 2019 18:78

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  25. Content type: Research

    Alzheimer’s disease (AD) is a progressive neurodegenerative disease, and due to various physiological and psychological factors the patients are at risk of nutritional insufficiencies. The purpose of this stud...

    Authors: Samar Rashed Alsumari, Doha Mustafa AlNouri, Mervat Mohamed Ali El-Sayed, Mohamed Fekry Serag El-Din and Shaista Arzoo

    Citation: Lipids in Health and Disease 2019 18:77

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  26. Content type: Research

    Numerous epidemiologic studies have found a close association between obesity and cancer. Dietary fat is a fundamental contributor to obesity and is a risk factor for cancer. Thus far, the impact of dietary ol...

    Authors: Xiaoyu Zhang, Ping Yang, Xuan Luo, Chunxiao Su, Yao Chen, Lei Zhao, Li Wei, Han Zeng, Zac Varghese, John F. Moorhead, Xiong Z. Ruan and Yaxi Chen

    Citation: Lipids in Health and Disease 2019 18:76

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  27. Content type: Research

    Previous studies have reported that an irregular work schedule, particularly nighttime work, is associated with an altered lipid profile. Additionally, a mismatch in circadian rhythm can affect sleeping and ea...

    Authors: Jae Hong Joo, Doo Woong Lee, Dong-Woo Choi and Eun-Cheol Park

    Citation: Lipids in Health and Disease 2019 18:75

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  28. Content type: Research

    CD14 polymorphisms are associated with an increased risk of cardiovascular events. So far, many studies have been conducted, whereas the results were not always consistent.

    Authors: Jin-Jian Xu, Ke-Qi Liu, Zhi-Min Ying, Xiao-Wei Zhu, Xue-Jin Xu, Pian-Pian Zhao, Wei-Yang Bai, Mo-Chang Qiu, Xing-Wei Zhang and Hou-Feng Zheng

    Citation: Lipids in Health and Disease 2019 18:74

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  29. Content type: Commentary

    Fetuin-A (FetA), which impairs insulin action is considered classically as a hepatokine. In patients with Metabolic Syndrome without the confounding of diabetes or cardiovascular diseases, we showed significan...

    Authors: Ishwarlal Jialal and Roma Pahwa

    Citation: Lipids in Health and Disease 2019 18:73

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  30. Content type: Research

    Few studies investigate sex difference in stroke incidence in rural China hypertensive population.

    Authors: Yali Wang, Yue Dai, Jia Zheng, Yanxia Xie, Rongrong Guo, Xiaofan Guo, Guozhe Sun, Zhaoqing Sun, Yingxian Sun and Liqiang Zheng

    Citation: Lipids in Health and Disease 2019 18:72

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  31. Content type: Research

    Obesity increases the risk of developing diabetes mellitus. Clinical studies suggest that risk factors like palmitic acid (PA) and lipopolysaccharide (LPS) exist simultaneously in diabetes with obesity. Combin...

    Authors: Xuehong Wang, Xin Jiang, Bin Deng, Juan Xiao, Junfei Jin and Zhaoquan Huang

    Citation: Lipids in Health and Disease 2019 18:71

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  32. Content type: Research

    This study aims to investigate the molecular mechanism of Adenovirus type 36 (Ad36) in adipocyte differentiation and glucolipid metabolism.

    Authors: Yi Jiao, Xiaodi Liang, Jianfei Hou, Yiliyasi Aisa, Han Wu, Zhilu Zhang, Nuerbiye Nuermaimaiti, Yang Zhao, Sheng Jiang and Yaqun Guan

    Citation: Lipids in Health and Disease 2019 18:70

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  33. Content type: Research

    To generate novel rabbit models with a large-fragment deletion of either LDL receptor (LDLR) and/or apolipoprotein (apoE) genes for the study of hyperlipidemic and atherosclerosis.

    Authors: Tingting Yuan, Yi Zhong, Yingge Wang, Ting Zhang, Rui Lu, Minya Zhou, Yaoyao Lu, Kunning Yan, Yajie Chen, Zhehui Hu, Jingyan Liang, Jianglin Fan and Yong Cheng

    Citation: Lipids in Health and Disease 2019 18:69

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  34. Content type: Research

    Hypertriglyceridemia (HTG) is one of the most common etiologies of acute pancreatitis (AP). Variants in five genes involved in the regulation of plasma lipid metabolism, namely LPL, APOA5, APOC2, GPIHBP1 and LMF1

    Authors: Wei-Wei Chen, Qi Yang, Xiao-Yao Li, Xiao-Lei Shi, Na Pu, Guo-Tao Lu, Zhi-Hui Tong, Jian-Min Chen and Wei-Qin Li

    Citation: Lipids in Health and Disease 2019 18:68

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  35. Content type: Research

    The infrapatellar fat pad (IFP) of the knee joint has received lots of attention recently due to its emerging role in the pathogenesis of osteoarthritis (OA), where it displays an inflammatory phenotype. The a...

    Authors: Anne-Mari Mustonen, Reijo Käkelä, Mikko A. J. Finnilä, Andrew Sawatsky, Rami K. Korhonen, Simo Saarakkala, Walter Herzog, Tommi Paakkonen and Petteri Nieminen

    Citation: Lipids in Health and Disease 2019 18:67

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  36. Content type: Research

    Nutraceuticals represent a new therapeutic frontier in the treatment of metabolic syndrom (MetS) and related cardiovascular risk factors. The aim of this study was to evaluate the potential beneficial effects ...

    Authors: Ferruccio Galletti, Valeria Fazio, Marco Gentile, Giuseppe Schillaci, Giacomo Pucci, Francesca Battista, Valentina Mercurio, Giorgio Bosso, Domenico Bonaduce, Nadia Brambilla, Cristina Vitalini, Massimo D’Amato and Giampaolo Giacovelli

    Citation: Lipids in Health and Disease 2019 18:66

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  37. Content type: Research

    Depression, metabolic disturbances and inflammation have been linked to cardiovascular disease and mortality. Low levels of high-density lipoprotein cholesterol (HDL-cholesterol), a known marker of cardiovascu...

    Authors: Eva Olga Melin, Hans Olav Thulesius, Magnus Hillman, Ralph Svensson, Mona Landin-Olsson and Maria Thunander

    Citation: Lipids in Health and Disease 2019 18:65

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  38. Content type: Research

    The importance of blood lipids in the pathogenesis of sudden sensorineural hearing loss (SSNHL) is widely discussed in the literature. However, the published results that hyperlipidaemia causes hearing problem...

    Authors: Anastasiya M. Kaneva, Yury K. Yanov, Svetlana G. Bojko, Olga E. Kudryavykh, Natalya N. Potolitsyna, Evgeny R. Bojko and Jon Ø. Odland

    Citation: Lipids in Health and Disease 2019 18:64

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  39. Content type: Research

    Both selenium (Se) and probiotic Bacillus regulate the metabolism to help defense clod stress and improve the meat quality in breeding chicks. The purpose of this study was to evaluate the effect of supplemental ...

    Authors: Jiajun Yang, Minhong Zhang and Ying Zhou

    Citation: Lipids in Health and Disease 2019 18:63

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  40. Content type: Research

    Endothelial-to-mesenchymal transition (EndMT) plays significant roles in atherosclerosis, but the regulatory mechanisms involving lncRNAs remain to be elucidated. Here we sort to identify the role of metastasi...

    Authors: Hongrong Li, Qifei Zhao, Liping Chang, Cong Wei, Hongying Bei, Yujie Yin, Meng Chen, Hongtao Wang, Junqing Liang and Yiling Wu

    Citation: Lipids in Health and Disease 2019 18:62

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  41. Content type: Research

    Dysregulation of the lipid homeostasis is an independent risk factor for non-alcoholic fatty liver disease (NAFLD). Some studies had demonstrated that TRIB1 gene polymorphisms affect the plasma lipids metabolism,...

    Authors: Qun Liu, Feng Xue, Jing Meng, Shou-Sheng Liu, Li-Zhen Chen, Hui Gao, Ning Geng, Wen-Wen Jin, Yong-Ning Xin and Shi-Ying Xuan

    Citation: Lipids in Health and Disease 2019 18:61

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  42. Content type: Research

    Chronic kidney disease (CKD) associates with complex lipoprotein disturbances resulting in high cardiovascular risk. Apolipoprotein E (APOE) is a polymorphic protein with three common isoforms (E2; E3; E4) tha...

    Authors: Monika Czaplińska, Agnieszka Ćwiklińska, Monika Sakowicz-Burkiewicz, Ewa Wieczorek, Agnieszka Kuchta, Robert Kowalski, Barbara Kortas-Stempak, Alicja Dębska-Ślizień, Maciej Jankowski and Ewa Król

    Citation: Lipids in Health and Disease 2019 18:60

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  43. Content type: Research

    Among the dietary lipids, milk fat is most complicated as it contains more than one hundred types of fatty acids and several triglycerides. Huge versatility in triglyceride and fatty composition makes it possi...

    Authors: Imran Taj Khan, Muhammad Nadeem, Muhammad Imran, Muhammad Asif, Muhammad Kamran Khan, Ahmad Din and Rahman Ullah

    Citation: Lipids in Health and Disease 2019 18:59

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  44. Content type: Research

    Cardiovascular and cerebrovascular diseases have become leading causes of death in China as the economy develop and lifestyles change. This study aimed to estimate the relationship of the age, gender, and gluc...

    Authors: Meijian Wang, Xinguo Hou, Wenchao Hu, Li Chen and Shihong Chen

    Citation: Lipids in Health and Disease 2019 18:58

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  45. Content type: Research

    Evidence regarding the relationship between estimated glomerular filtration rate (eGFR) and arterial stiffness is limited, and the data analysis is not sufficient to clarify the true relationship between the t...

    Authors: Yun-Fen Chen and Chi Chen

    Citation: Lipids in Health and Disease 2019 18:57

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  46. Content type: Research

    ω-3 polyunsaturated fatty acids (PUFAs) are synthesized from α-Linolenic acid (ALA, C18:3ω3) and play important roles in anti-inflammatory and antioxidant responses in mammal cells. ALA is an essential fatty a...

    Authors: Yimeng Lin, Jingping Ge, Yunye Zhang, Hongzhi Ling, Xiufeng Yan and Wenxiang Ping

    Citation: Lipids in Health and Disease 2019 18:56

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